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Measuring inhomogeneous MT (ihMT) in human brain by multi-parameter mapping (MPM)

Helms, Gunther LU orcid ; Vaculčiaková, Lenka ; Pine, Kerrin J. ; Moeller, Harald E. and Weiskopf, Nikolaus (2021) In Proc Intl Soc Magn Reson Med 29.
Abstract
Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is sensitive to myelination. Quantification of ihMT in terms of MT saturation (MTsat), the percent reduction of Mz, corrects for underlying T1 and B1+ and allows comparing different implementations to optimize multi-parameter mapping (MPM) protocols. ihMTsat in white matter is roughly one twentieth of MTsat, merely 0.2 p.u. at 5kHz and 100% SAR at 3T. Noise propagation demands acquisition at 1.5mm resolution, large-array coils, and smaller offsets than suggested previously. Inverse MT ratios are highly correlated to ihMTs but obscure the true effect size.
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author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the 2021 ISMRM & ISMRT Annual Meeting and Exhibition
series title
Proc Intl Soc Magn Reson Med
volume
29
article number
1840
publisher
International Society for Magnetic Resonance in Medicine
ISSN
1545-4428
language
English
LU publication?
yes
id
3c1156b9-57c9-4255-b390-48239068ed7d
alternative location
https://index.mirasmart.com/ISMRM2021/PDFfiles/1840.html
date added to LUP
2021-05-18 21:03:52
date last changed
2022-03-16 14:03:53
@inproceedings{3c1156b9-57c9-4255-b390-48239068ed7d,
  abstract     = {{Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is sensitive to myelination. Quantification of ihMT in terms of MT saturation (MTsat), the percent reduction of Mz, corrects for underlying T<sub>1</sub> and B<sub>1</sub><sup>+</sup> and allows comparing different implementations to optimize multi-parameter mapping (MPM) protocols. ihMTsat in white matter is roughly one twentieth of MTsat, merely 0.2 p.u. at 5kHz and 100% SAR at 3T. Noise propagation demands acquisition at 1.5mm resolution, large-array coils, and smaller offsets than suggested previously. Inverse MT ratios are highly correlated to ihMTs but obscure the true effect size.}},
  author       = {{Helms, Gunther and Vaculčiaková, Lenka and Pine, Kerrin J. and Moeller, Harald E. and Weiskopf, Nikolaus}},
  booktitle    = {{Proceedings of the 2021 ISMRM & ISMRT Annual Meeting and Exhibition}},
  issn         = {{1545-4428}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{International Society for Magnetic Resonance in Medicine}},
  series       = {{Proc Intl Soc Magn Reson Med}},
  title        = {{Measuring inhomogeneous MT (ihMT) in human brain by multi-parameter mapping (MPM)}},
  url          = {{https://index.mirasmart.com/ISMRM2021/PDFfiles/1840.html}},
  volume       = {{29}},
  year         = {{2021}},
}