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Population-level effects of human papillomavirus vaccination programs on infections with nonvaccine genotypes

Mesher, David; Soldan, Kate; Lehtinen, Matti; Beddows, Simon; Brisson, Marc; Brotherton, Julia M L; Chow, Eric P F; Cummings, Teresa; Drolet, Mélanie and Fairley, Christopher K., et al. (2016) In Emerging Infectious Diseases 22(10). p.1732-1740
Abstract

We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20–24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age... (More)

We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20–24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age groups and vaccines used were inconsistent, and the increases had possible alternative explanations; consequently, these data provided no clear evidence for type replacement. Continued monitoring of these HPV genotypes is important.

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Emerging Infectious Diseases
volume
22
issue
10
pages
9 pages
publisher
Centers for Disease Control and Prevention
external identifiers
  • scopus:84988530527
ISSN
1080-6040
DOI
10.3201/eid2210.160675
language
English
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yes
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3c209bcf-8f1c-44e3-90dc-0bd9d919972e
date added to LUP
2016-10-19 09:10:38
date last changed
2017-10-29 04:52:58
@article{3c209bcf-8f1c-44e3-90dc-0bd9d919972e,
  abstract     = {<p>We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20–24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age groups and vaccines used were inconsistent, and the increases had possible alternative explanations; consequently, these data provided no clear evidence for type replacement. Continued monitoring of these HPV genotypes is important.</p>},
  author       = {Mesher, David and Soldan, Kate and Lehtinen, Matti and Beddows, Simon and Brisson, Marc and Brotherton, Julia M L and Chow, Eric P F and Cummings, Teresa and Drolet, Mélanie and Fairley, Christopher K. and Garland, Suzanne M. and Kahn, Jessica A. and Kavanagh, Kimberley and Markowitz, Lauri and Pollock, Kevin G. and Söderlund-Strand, Anna and Sonnenberg, Pam and Tabrizi, Sepehr N. and Tanton, Clare and Unger, Elizabeth and Thomas, Sara L.},
  issn         = {1080-6040},
  language     = {eng},
  month        = {10},
  number       = {10},
  pages        = {1732--1740},
  publisher    = {Centers for Disease Control and Prevention},
  series       = {Emerging Infectious Diseases},
  title        = {Population-level effects of human papillomavirus vaccination programs on infections with nonvaccine genotypes},
  url          = {http://dx.doi.org/10.3201/eid2210.160675},
  volume       = {22},
  year         = {2016},
}