Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis
(2020) In JACC: Basic to Translational Science 5(7). p.649-661- Abstract
The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with noncarriers. PCSK9 expression was higher in the aortic valves of patients CAVS compared with control patients. In human valve interstitials cells submitted to a pro-osteogenic medium, PCSK9 levels increased and a PCSK9 neutralizing antibody significantly reduced calcium accumulation.
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- author
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aortic valve interstitial cell, apolipoprotein B, calcific aortic valve stenosis, LDL cholesterol, lipoprotein(a), proprotein convertase subtilisin/kexin type 9
- in
- JACC: Basic to Translational Science
- volume
- 5
- issue
- 7
- pages
- 13 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:32760854
- scopus:85087405073
- ISSN
- 2452-302X
- DOI
- 10.1016/j.jacbts.2020.05.004
- language
- English
- LU publication?
- yes
- id
- 3c23e2f1-5101-4798-af05-5f7e4b4d1448
- date added to LUP
- 2020-12-29 13:44:34
- date last changed
- 2024-09-19 12:17:39
@article{3c23e2f1-5101-4798-af05-5f7e4b4d1448, abstract = {{<p>The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with noncarriers. PCSK9 expression was higher in the aortic valves of patients CAVS compared with control patients. In human valve interstitials cells submitted to a pro-osteogenic medium, PCSK9 levels increased and a PCSK9 neutralizing antibody significantly reduced calcium accumulation.</p>}}, author = {{Perrot, Nicolas and Valerio, Vincenza and Moschetta, Donato and Boekholdt, S. Matthijs and Dina, Christian and Chen, Hao Yu and Abner, Erik and Martinsson, Andreas and Manikpurage, Hasanga D. and Rigade, Sidwell and Capoulade, Romain and Mass, Elvira and Clavel, Marie Annick and Le Tourneau, Thierry and Messika-Zeitoun, David and Wareham, Nicholas J. and Engert, James C. and Polvani, Gianluca and Pibarot, Philippe and Esko, Tõnu and Smith, J. Gustav and Mathieu, Patrick and Thanassoulis, George and Schott, Jean Jacques and Bossé, Yohan and Camera, Marina and Thériault, Sébastien and Poggio, Paolo and Arsenault, Benoit J.}}, issn = {{2452-302X}}, keywords = {{aortic valve interstitial cell; apolipoprotein B; calcific aortic valve stenosis; LDL cholesterol; lipoprotein(a); proprotein convertase subtilisin/kexin type 9}}, language = {{eng}}, number = {{7}}, pages = {{649--661}}, publisher = {{Elsevier}}, series = {{JACC: Basic to Translational Science}}, title = {{Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis}}, url = {{http://dx.doi.org/10.1016/j.jacbts.2020.05.004}}, doi = {{10.1016/j.jacbts.2020.05.004}}, volume = {{5}}, year = {{2020}}, }