Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Going to extremes - a metagenomic journey into the dark matter of life

Aevarsson, Arnthór ; Kaczorowska, Anna-Karina ; Adalsteinsson, Björn Thor ; Ahlqvist, Josefin LU ; Al-Karadaghi, Salam LU ; Altenbuchner, Joseph ; Arsin, Hasan ; Átlasson, Úlfur Áugúst ; Brandt, David and Cichowicz-Cieślak, Magdalena , et al. (2021) In FEMS Microbiology Letters 368(12).
Abstract

The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included... (More)

The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
FEMS Microbiology Letters
volume
368
issue
12
article number
fnab067
pages
16 pages
publisher
Oxford University Press
external identifiers
  • scopus:85109117639
  • pmid:34114607
ISSN
1574-6968
DOI
10.1093/femsle/fnab067
language
English
LU publication?
yes
id
3c294811-60dd-4f95-be49-485708492d40
date added to LUP
2021-07-01 20:39:31
date last changed
2024-06-15 13:09:58
@article{3c294811-60dd-4f95-be49-485708492d40,
  abstract     = {{<p>The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.</p>}},
  author       = {{Aevarsson, Arnthór and Kaczorowska, Anna-Karina and Adalsteinsson, Björn Thor and Ahlqvist, Josefin and Al-Karadaghi, Salam and Altenbuchner, Joseph and Arsin, Hasan and Átlasson, Úlfur Áugúst and Brandt, David and Cichowicz-Cieślak, Magdalena and Cornish, Katy A S and Courtin, Jérémy and Dabrowski, Slawomir and Dahle, Håkon and Djeffane, Samia and Dorawa, Sebastian and Dusaucy, Julia and Enault, Francois and Fedøy, Anita-Elin and Freitag-Pohl, Stefanie and Fridjonsson, Olafur H and Galiez, Clovis and Glomsaker, Eirin and Guérin, Mickael and Gundesø, Sigurd E and Gudmundsdóttir, Elisabet E and Gudmundsson, Hördur and Håkansson, Maria and Henke, Christian and Helleux, Alexandra and Henriksen, Jørn Remi and Hjörleifdóttir, Sigrídur and Hreggvidsson, Gudmundur O and Jasilionis, Andrius and Jochheim, Annika and Jónsdóttir, Ilmur and Jónsdóttir, Lilja Björk and Jurczak-Kurek, Agata and Kaczorowski, Tadeusz and Kalinowski, Jörn and Kozlowski, Lukasz P and Krupovic, Mart and Kwiatkowska-Semrau, Karolina and Lanes, Olav and Linares-Pastén, Javier and Karlsson, Eva Nordberg and Skírnisdóttir, Sigurlaug and Svensson, Anders and Walse, Björn and Welin, Martin and Zhang, Ruoshi}},
  issn         = {{1574-6968}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{12}},
  publisher    = {{Oxford University Press}},
  series       = {{FEMS Microbiology Letters}},
  title        = {{Going to extremes - a metagenomic journey into the dark matter of life}},
  url          = {{http://dx.doi.org/10.1093/femsle/fnab067}},
  doi          = {{10.1093/femsle/fnab067}},
  volume       = {{368}},
  year         = {{2021}},
}