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Comparison of the toxicities of ethylene vinyl alcohol copolymer (EVOH) preparations, dimethyl sulphoxide and N-butyl 2-cyanoacrylate on cerebral parenchyma in an experimental rabbit model

Ozdol, Cagatay ; Turk, Cezmi Cagri ; Hazer, Derya Burcu LU orcid ; Yildirim, Ali Erdem ; Arat, Anil ; Atilla, Pergin ; Muftuoglu, Sevda and Oruckaptan, Hakan (2015) In Turkish Neurosurgery 25(3). p.446-452
Abstract

AIM: Ethylene vinyl alcohol copolymer (EVOH), its organic solvent dimethyl sulfoxide (DMSO), and N-Butyl 2-Cyanoacrylate (NBCA) are widely used in neurovascular embolization procedures and yet with potential risk of cytotoxicity. The aim of this study was to evaluate the toxic effect of EVOH-DMSO, its solvent DMSO and NBCA on cerebral parenchyma in a rabbit model. MATERIAL and METHODS: Forty-eight albino male rabbits were divided into 6 groups based on the substance injected into the parenchyma; normal saline, DMSO, NBCA, 6% EVOH-DMSO and 20% EVOH-DMSO and control group. At 72 hours the subjects were sacrificed and brain samples were harvested for histopathological examination and lipid peroxidase measurements. RESULTS: Neuronal... (More)

AIM: Ethylene vinyl alcohol copolymer (EVOH), its organic solvent dimethyl sulfoxide (DMSO), and N-Butyl 2-Cyanoacrylate (NBCA) are widely used in neurovascular embolization procedures and yet with potential risk of cytotoxicity. The aim of this study was to evaluate the toxic effect of EVOH-DMSO, its solvent DMSO and NBCA on cerebral parenchyma in a rabbit model. MATERIAL and METHODS: Forty-eight albino male rabbits were divided into 6 groups based on the substance injected into the parenchyma; normal saline, DMSO, NBCA, 6% EVOH-DMSO and 20% EVOH-DMSO and control group. At 72 hours the subjects were sacrificed and brain samples were harvested for histopathological examination and lipid peroxidase measurements. RESULTS: Neuronal degeneration and inflammatory reaction in the brain parenchyma was prominent especially in DMSO group and EVOHDMSO groups. Furthermore, the extent of degeneration and inflammatory reaction was related to the concentration of the embolic agent in the EVOH group. Lipid peroxidase activity was significantly increased in the NBCA group as compared to all but to 20 % EVOH-DMSO group. CONCLUSION: EVOH and its solvent DMSO cause degeneration and inflammatory reaction in brain parenchyma and for EVOH this reaction was appeared to be dose dependent.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
Cerebral parenchyma, Cerebrovascular diseases, DMSO, Embolization, Ethylene vinyl alcohol copolymer, N-Butyl 2-Cyanoacrylate, Toxicity
in
Turkish Neurosurgery
volume
25
issue
3
pages
446 - 452
publisher
Turkish Neurosurgical Society
external identifiers
  • scopus:84930726450
  • pmid:26037186
ISSN
1019-5149
DOI
10.5137/1019-5149.JTN.12592-14.1
language
English
LU publication?
no
id
3c381655-6f4f-475b-a557-1b87c8761696
date added to LUP
2025-05-11 22:36:30
date last changed
2025-06-09 01:29:56
@article{3c381655-6f4f-475b-a557-1b87c8761696,
  abstract     = {{<p>AIM: Ethylene vinyl alcohol copolymer (EVOH), its organic solvent dimethyl sulfoxide (DMSO), and N-Butyl 2-Cyanoacrylate (NBCA) are widely used in neurovascular embolization procedures and yet with potential risk of cytotoxicity. The aim of this study was to evaluate the toxic effect of EVOH-DMSO, its solvent DMSO and NBCA on cerebral parenchyma in a rabbit model. MATERIAL and METHODS: Forty-eight albino male rabbits were divided into 6 groups based on the substance injected into the parenchyma; normal saline, DMSO, NBCA, 6% EVOH-DMSO and 20% EVOH-DMSO and control group. At 72 hours the subjects were sacrificed and brain samples were harvested for histopathological examination and lipid peroxidase measurements. RESULTS: Neuronal degeneration and inflammatory reaction in the brain parenchyma was prominent especially in DMSO group and EVOHDMSO groups. Furthermore, the extent of degeneration and inflammatory reaction was related to the concentration of the embolic agent in the EVOH group. Lipid peroxidase activity was significantly increased in the NBCA group as compared to all but to 20 % EVOH-DMSO group. CONCLUSION: EVOH and its solvent DMSO cause degeneration and inflammatory reaction in brain parenchyma and for EVOH this reaction was appeared to be dose dependent.</p>}},
  author       = {{Ozdol, Cagatay and Turk, Cezmi Cagri and Hazer, Derya Burcu and Yildirim, Ali Erdem and Arat, Anil and Atilla, Pergin and Muftuoglu, Sevda and Oruckaptan, Hakan}},
  issn         = {{1019-5149}},
  keywords     = {{Cerebral parenchyma; Cerebrovascular diseases; DMSO; Embolization; Ethylene vinyl alcohol copolymer; N-Butyl 2-Cyanoacrylate; Toxicity}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{446--452}},
  publisher    = {{Turkish Neurosurgical Society}},
  series       = {{Turkish Neurosurgery}},
  title        = {{Comparison of the toxicities of ethylene vinyl alcohol copolymer (EVOH) preparations, dimethyl sulphoxide and N-butyl 2-cyanoacrylate on cerebral parenchyma in an experimental rabbit model}},
  url          = {{http://dx.doi.org/10.5137/1019-5149.JTN.12592-14.1}},
  doi          = {{10.5137/1019-5149.JTN.12592-14.1}},
  volume       = {{25}},
  year         = {{2015}},
}