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An agnostic study of associations between abo and rhd blood group and phenome-wide disease risk

Dahlén, Torsten ; Clements, Mark ; Zhao, Jingcheng ; Olsson, Martin L. LU orcid and Edgren, Gustaf (2021) In eLife 10.
Abstract

Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on... (More)

Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Conclusion: Our findings generate strong further support for previously known associations, but also indicate new interesting relations.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ABO, Agnostic, Disease occurrence, Phenome-wide study, RhD
in
eLife
volume
10
article number
e65658
publisher
eLife Sciences Publications
external identifiers
  • scopus:85105701434
  • pmid:33902814
ISSN
2050-084X
DOI
10.7554/ELIFE.65658
language
English
LU publication?
yes
id
3c95afc1-1e92-493d-99db-98900aecef6d
date added to LUP
2021-06-01 11:03:54
date last changed
2024-06-15 11:51:52
@article{3c95afc1-1e92-493d-99db-98900aecef6d,
  abstract     = {{<p>Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Conclusion: Our findings generate strong further support for previously known associations, but also indicate new interesting relations.</p>}},
  author       = {{Dahlén, Torsten and Clements, Mark and Zhao, Jingcheng and Olsson, Martin L. and Edgren, Gustaf}},
  issn         = {{2050-084X}},
  keywords     = {{ABO; Agnostic; Disease occurrence; Phenome-wide study; RhD}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{eLife Sciences Publications}},
  series       = {{eLife}},
  title        = {{An agnostic study of associations between abo and rhd blood group and phenome-wide disease risk}},
  url          = {{http://dx.doi.org/10.7554/ELIFE.65658}},
  doi          = {{10.7554/ELIFE.65658}},
  volume       = {{10}},
  year         = {{2021}},
}