An agnostic study of associations between abo and rhd blood group and phenome-wide disease risk
(2021) In eLife 10.- Abstract
Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on... (More)
Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Conclusion: Our findings generate strong further support for previously known associations, but also indicate new interesting relations.
(Less)
- author
- Dahlén, Torsten ; Clements, Mark ; Zhao, Jingcheng ; Olsson, Martin L. LU and Edgren, Gustaf
- organization
- publishing date
- 2021-04-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ABO, Agnostic, Disease occurrence, Phenome-wide study, RhD
- in
- eLife
- volume
- 10
- article number
- e65658
- publisher
- eLife Sciences Publications
- external identifiers
-
- scopus:85105701434
- pmid:33902814
- ISSN
- 2050-084X
- DOI
- 10.7554/ELIFE.65658
- language
- English
- LU publication?
- yes
- id
- 3c95afc1-1e92-493d-99db-98900aecef6d
- date added to LUP
- 2021-06-01 11:03:54
- date last changed
- 2024-09-07 19:57:05
@article{3c95afc1-1e92-493d-99db-98900aecef6d, abstract = {{<p>Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Conclusion: Our findings generate strong further support for previously known associations, but also indicate new interesting relations.</p>}}, author = {{Dahlén, Torsten and Clements, Mark and Zhao, Jingcheng and Olsson, Martin L. and Edgren, Gustaf}}, issn = {{2050-084X}}, keywords = {{ABO; Agnostic; Disease occurrence; Phenome-wide study; RhD}}, language = {{eng}}, month = {{04}}, publisher = {{eLife Sciences Publications}}, series = {{eLife}}, title = {{An agnostic study of associations between abo and rhd blood group and phenome-wide disease risk}}, url = {{http://dx.doi.org/10.7554/ELIFE.65658}}, doi = {{10.7554/ELIFE.65658}}, volume = {{10}}, year = {{2021}}, }