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Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer : a multicenter retrospective cohort study

Fujimoto, Hiroki ; Yoshihara, Masato ; Ricciardelli, Carmela ; Tano, Sho ; Iyoshi, Shohei ; Miyamoto, Emiri ; Mogi, Kazumasa ; Hayashi, Maia ; Hayakawa, Sae and Nomura, Satoshi , et al. (2024) In Scientific Reports 14(1).
Abstract

Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impact on peritoneal recurrence after combined cytoreductive surgery and chemotherapy is not clear. The objective of this study was to investigate the impact of aging on peritoneal recurrence from stealth dissemination and gain insight of the pathophysiology of OvCa in elderly patients. A total of 243 patients with pT2b-pT3 epithelial ovarian who achieved complete surgery, no-residual tumor at first surgery, were selected to be analyzed the risk of peritoneal seeding and recurrence. We found that age over... (More)

Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impact on peritoneal recurrence after combined cytoreductive surgery and chemotherapy is not clear. The objective of this study was to investigate the impact of aging on peritoneal recurrence from stealth dissemination and gain insight of the pathophysiology of OvCa in elderly patients. A total of 243 patients with pT2b-pT3 epithelial ovarian who achieved complete surgery, no-residual tumor at first surgery, were selected to be analyzed the risk of peritoneal seeding and recurrence. We found that age over 65 years was independently associated with an increased risk of peritoneum-specific (PS) recurrence (. Furthermore, pT3 stages and positive ascites cytology also worsen the PS-relapse-free survival. Collectively, our findings suggest that age, especially over 65 years, predicts reduced peritoneum-specific tumor recurrence in patients with advanced ovarian cancer after complete cytoreduction surgery, particularly those with pT3 tumors and positive ascites cytology.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Ovarian cancer, Peritoneal dissemination, Recurrence
in
Scientific Reports
volume
14
issue
1
article number
23537
publisher
Nature Publishing Group
external identifiers
  • pmid:39384823
  • scopus:85205960479
ISSN
2045-2322
DOI
10.1038/s41598-024-66419-w
language
English
LU publication?
yes
id
3cac54ba-047d-4148-82c3-6de05bcfa5e4
date added to LUP
2024-11-26 13:56:52
date last changed
2025-01-27 12:51:46
@article{3cac54ba-047d-4148-82c3-6de05bcfa5e4,
  abstract     = {{<p>Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impact on peritoneal recurrence after combined cytoreductive surgery and chemotherapy is not clear. The objective of this study was to investigate the impact of aging on peritoneal recurrence from stealth dissemination and gain insight of the pathophysiology of OvCa in elderly patients. A total of 243 patients with pT2b-pT3 epithelial ovarian who achieved complete surgery, no-residual tumor at first surgery, were selected to be analyzed the risk of peritoneal seeding and recurrence. We found that age over 65 years was independently associated with an increased risk of peritoneum-specific (PS) recurrence (. Furthermore, pT3 stages and positive ascites cytology also worsen the PS-relapse-free survival. Collectively, our findings suggest that age, especially over 65 years, predicts reduced peritoneum-specific tumor recurrence in patients with advanced ovarian cancer after complete cytoreduction surgery, particularly those with pT3 tumors and positive ascites cytology.</p>}},
  author       = {{Fujimoto, Hiroki and Yoshihara, Masato and Ricciardelli, Carmela and Tano, Sho and Iyoshi, Shohei and Miyamoto, Emiri and Mogi, Kazumasa and Hayashi, Maia and Hayakawa, Sae and Nomura, Satoshi and Kitami, Kazuhisa and Uno, Kaname and Yoshikawa, Nobuhisa and Emoto, Ryo and Matsui, Shigeyuki and Kajiyama, Hiroaki}},
  issn         = {{2045-2322}},
  keywords     = {{Aging; Ovarian cancer; Peritoneal dissemination; Recurrence}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer : a multicenter retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-66419-w}},
  doi          = {{10.1038/s41598-024-66419-w}},
  volume       = {{14}},
  year         = {{2024}},
}