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The Emergence of Hypervirulent M1T1 Clone of Group A Streptococcus via Genetic Recombination and Host Selection

Liu, Guanghui LU (2019) In Current Issues in Molecular Biology 32. p.435-472
Abstract

Streptococcus pyogenes (Group A Streptococcus, GAS) is a strictly human bacterial pathogen. Since the mid-1980s, GAS M1T1 clone has been the most prevalent and globally disseminated serotype and is the culprit causing invasive and severe streptococcal infections, urging a better understanding of the emergence of hypervirulent M1T1 clone from an evolutionary perspective. This review highlights the molecular and evolutionary events leading to pandemic M1T1 strains, and discusses the pressure driving the genetic acquisition of novel virulence genes and the selection of hypervirulent isolates in host. By understanding the evolutionary selection and pressures that select and shape the pandemic M1T1 clone, we could potentially develop new... (More)

Streptococcus pyogenes (Group A Streptococcus, GAS) is a strictly human bacterial pathogen. Since the mid-1980s, GAS M1T1 clone has been the most prevalent and globally disseminated serotype and is the culprit causing invasive and severe streptococcal infections, urging a better understanding of the emergence of hypervirulent M1T1 clone from an evolutionary perspective. This review highlights the molecular and evolutionary events leading to pandemic M1T1 strains, and discusses the pressure driving the genetic acquisition of novel virulence genes and the selection of hypervirulent isolates in host. By understanding the evolutionary selection and pressures that select and shape the pandemic M1T1 clone, we could potentially develop new therapeutic strategies to tackle challenges when dealing with the globally disseminated M1T1 GAS clone.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Issues in Molecular Biology
volume
32
pages
38 pages
publisher
MDPI AG
external identifiers
  • pmid:31166177
  • scopus:85078509775
ISSN
1467-3037
DOI
10.21775/cimb.032.435
language
English
LU publication?
yes
id
3cad98ae-5d15-4f7e-8046-670acff1ff76
date added to LUP
2020-02-03 15:38:58
date last changed
2022-08-03 20:32:48
@article{3cad98ae-5d15-4f7e-8046-670acff1ff76,
  abstract     = {{<p>Streptococcus pyogenes (Group A Streptococcus, GAS) is a strictly human bacterial pathogen. Since the mid-1980s, GAS M1T1 clone has been the most prevalent and globally disseminated serotype and is the culprit causing invasive and severe streptococcal infections, urging a better understanding of the emergence of hypervirulent M1T1 clone from an evolutionary perspective. This review highlights the molecular and evolutionary events leading to pandemic M1T1 strains, and discusses the pressure driving the genetic acquisition of novel virulence genes and the selection of hypervirulent isolates in host. By understanding the evolutionary selection and pressures that select and shape the pandemic M1T1 clone, we could potentially develop new therapeutic strategies to tackle challenges when dealing with the globally disseminated M1T1 GAS clone.</p>}},
  author       = {{Liu, Guanghui}},
  issn         = {{1467-3037}},
  language     = {{eng}},
  pages        = {{435--472}},
  publisher    = {{MDPI AG}},
  series       = {{Current Issues in Molecular Biology}},
  title        = {{The Emergence of Hypervirulent M1T1 Clone of Group A Streptococcus via Genetic Recombination and Host Selection}},
  url          = {{http://dx.doi.org/10.21775/cimb.032.435}},
  doi          = {{10.21775/cimb.032.435}},
  volume       = {{32}},
  year         = {{2019}},
}