Cooling strategies during neonatal transport for hypoxic-ischaemic encephalopathy
Sibrecht, Greta ; Borys, Franciszek ; Campone, Chiara ; Bellini, Carlo ; Davis, Peter and Bruschettini, Matteo LU
(2023)
In Acta Paediatrica, International Journal of Paediatrics
112(4).
p.587-602
- Abstract
Aim: We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia. Methods: The electronic databases CENTRAL, MEDLINE, Embase, CINAHL, and Scopus were searched from inception up to 8 March 2022 for studies comparing cooling versus no cooling, active versus passive cooling, and servo-controlled versus non-servo-controlled cooling. Odds ratio and confidence of interval were calculated for dichotomous outcomes and mean difference and confidence interval for continuous outcomes. Results: The final analysis included 14 studies, 1 randomised and 13 non-randomised,... (More)
Aim: We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia. Methods: The electronic databases CENTRAL, MEDLINE, Embase, CINAHL, and Scopus were searched from inception up to 8 March 2022 for studies comparing cooling versus no cooling, active versus passive cooling, and servo-controlled versus non-servo-controlled cooling. Odds ratio and confidence of interval were calculated for dichotomous outcomes and mean difference and confidence interval for continuous outcomes. Results: The final analysis included 14 studies, 1 randomised and 13 non-randomised, involving 1098 newborn infants. Compared with the other cooling methods, servo-controlled active cooling was more likely to maintain body temperature within the target range of 33°C–34°C on arrival at a neonatal intensive care unit: odds ratio 13.58, 95% confidence interval 4.32–42.66, risk difference 0.33, 95% confidence interval 0.19–0.46; 224 participants; three studies; I2 0%. The certainty of evidence was low. Only five studies reported mortality rates. Conclusion: Servo-controlled active cooling may be the preferred method during transport of newborn infants with HIE. A future area of focus should be long-term neurodevelopmental outcomes after servo-controlled active cooling.
(Less)
- author
- Sibrecht, Greta
; Borys, Franciszek
; Campone, Chiara
; Bellini, Carlo
; Davis, Peter
and Bruschettini, Matteo
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hypoxic-ischaemic encephalopathy, neonatal transport, systematic review, therapeutic hypothermia
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 112
- issue
- 4
- pages
- 587 - 602
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:36527301
- scopus:85145303623
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.16632
- language
- English
- LU publication?
- yes
- id
- 3d06503a-2413-4318-b869-9f72b11bc242
- date added to LUP
- 2023-02-09 13:40:15
- date last changed
- 2024-04-30 09:18:32
@article{3d06503a-2413-4318-b869-9f72b11bc242,
abstract = {{<p>Aim: We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia. Methods: The electronic databases CENTRAL, MEDLINE, Embase, CINAHL, and Scopus were searched from inception up to 8 March 2022 for studies comparing cooling versus no cooling, active versus passive cooling, and servo-controlled versus non-servo-controlled cooling. Odds ratio and confidence of interval were calculated for dichotomous outcomes and mean difference and confidence interval for continuous outcomes. Results: The final analysis included 14 studies, 1 randomised and 13 non-randomised, involving 1098 newborn infants. Compared with the other cooling methods, servo-controlled active cooling was more likely to maintain body temperature within the target range of 33°C–34°C on arrival at a neonatal intensive care unit: odds ratio 13.58, 95% confidence interval 4.32–42.66, risk difference 0.33, 95% confidence interval 0.19–0.46; 224 participants; three studies; I<sup>2</sup> 0%. The certainty of evidence was low. Only five studies reported mortality rates. Conclusion: Servo-controlled active cooling may be the preferred method during transport of newborn infants with HIE. A future area of focus should be long-term neurodevelopmental outcomes after servo-controlled active cooling.</p>}},
author = {{Sibrecht, Greta and Borys, Franciszek and Campone, Chiara and Bellini, Carlo and Davis, Peter and Bruschettini, Matteo}},
issn = {{0803-5253}},
keywords = {{hypoxic-ischaemic encephalopathy; neonatal transport; systematic review; therapeutic hypothermia}},
language = {{eng}},
number = {{4}},
pages = {{587--602}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Cooling strategies during neonatal transport for hypoxic-ischaemic encephalopathy}},
url = {{http://dx.doi.org/10.1111/apa.16632}},
doi = {{10.1111/apa.16632}},
volume = {{112}},
year = {{2023}},
}