Exercise and internet-based cognitive-behavioural therapy for depression : Multicentre randomized controlled trial with 12-month follow-up
(2016) In British Journal of Psychiatry 209(5). p.414-420- Abstract
Background Evidence-based treatment of depression continues to grow, but successful treatment and maintenance of treatment response remains limited. Aims To compare the effectiveness of exercise, internet-based cognitive-behavioural therapy (ICBT) and usual care for depression. Method A multicentre, three-group parallel, randomised controlled trial was conducted with assessment at 3 months (posttreatment) and 12 months (primary end-point). Outcome assessors were masked to group allocation. Computergenerated allocation was performed externally in blocks of 36 and the ratio of participants per group was 1:1:1. In total, 945 adults with mild to moderate depression aged 18-71 years were recruited from primary healthcare centres located... (More)
Background Evidence-based treatment of depression continues to grow, but successful treatment and maintenance of treatment response remains limited. Aims To compare the effectiveness of exercise, internet-based cognitive-behavioural therapy (ICBT) and usual care for depression. Method A multicentre, three-group parallel, randomised controlled trial was conducted with assessment at 3 months (posttreatment) and 12 months (primary end-point). Outcome assessors were masked to group allocation. Computergenerated allocation was performed externally in blocks of 36 and the ratio of participants per group was 1:1:1. In total, 945 adults with mild to moderate depression aged 18-71 years were recruited from primary healthcare centres located throughout Sweden. Participants were randomly assigned to one of three 12-week interventions: supervised group exercise, clinician-supported ICBT or usual care by a physician. The primary outcome was depression severity assessed by the Montgomery-Å sberg Depression Rating Scale (MADRS). Results The response rate at 12-month follow-up was 84%. Depression severity reduced significantly in all three treatment groups in a quadratic trend over time. Mean differences in MADRS score at 12 months were 12.1 (ICBT), 11.4 (exercise) and 9.7 (usual care). At the primary end-point the group6time interaction was significant for both exercise and ICBT. Effect sizes for both interventions were small to moderate. Conclusions The long-term treatment effects reported here suggest that prescribed exercise and clinician-supported ICBT should be considered for the treatment of mild to moderate depression in adults. Declaration of interest None.
(Less)
- author
- Hallgren, Mats ; Helgadóttir, Björg ; Herring, Matthew P. ; Zeebari, Zangin ; Lindefors, Nils ; Kaldo, Viktor ; Öjehagen, Agneta LU and Forsell, Yvonne
- organization
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Psychiatry
- volume
- 209
- issue
- 5
- pages
- 7 pages
- publisher
- Cambridge University Press
- external identifiers
-
- scopus:84996560150
- pmid:27609813
- wos:000387934500009
- ISSN
- 0007-1250
- DOI
- 10.1192/bjp.bp.115.177576
- language
- English
- LU publication?
- yes
- id
- 3d25b3e0-1e48-4cf3-87e1-4e56b48b26f6
- date added to LUP
- 2016-12-12 11:16:28
- date last changed
- 2024-12-15 15:48:27
@article{3d25b3e0-1e48-4cf3-87e1-4e56b48b26f6,
abstract = {{<p>Background Evidence-based treatment of depression continues to grow, but successful treatment and maintenance of treatment response remains limited. Aims To compare the effectiveness of exercise, internet-based cognitive-behavioural therapy (ICBT) and usual care for depression. Method A multicentre, three-group parallel, randomised controlled trial was conducted with assessment at 3 months (posttreatment) and 12 months (primary end-point). Outcome assessors were masked to group allocation. Computergenerated allocation was performed externally in blocks of 36 and the ratio of participants per group was 1:1:1. In total, 945 adults with mild to moderate depression aged 18-71 years were recruited from primary healthcare centres located throughout Sweden. Participants were randomly assigned to one of three 12-week interventions: supervised group exercise, clinician-supported ICBT or usual care by a physician. The primary outcome was depression severity assessed by the Montgomery-Å sberg Depression Rating Scale (MADRS). Results The response rate at 12-month follow-up was 84%. Depression severity reduced significantly in all three treatment groups in a quadratic trend over time. Mean differences in MADRS score at 12 months were 12.1 (ICBT), 11.4 (exercise) and 9.7 (usual care). At the primary end-point the group6time interaction was significant for both exercise and ICBT. Effect sizes for both interventions were small to moderate. Conclusions The long-term treatment effects reported here suggest that prescribed exercise and clinician-supported ICBT should be considered for the treatment of mild to moderate depression in adults. Declaration of interest None.</p>}},
author = {{Hallgren, Mats and Helgadóttir, Björg and Herring, Matthew P. and Zeebari, Zangin and Lindefors, Nils and Kaldo, Viktor and Öjehagen, Agneta and Forsell, Yvonne}},
issn = {{0007-1250}},
language = {{eng}},
month = {{11}},
number = {{5}},
pages = {{414--420}},
publisher = {{Cambridge University Press}},
series = {{British Journal of Psychiatry}},
title = {{Exercise and internet-based cognitive-behavioural therapy for depression : Multicentre randomized controlled trial with 12-month follow-up}},
url = {{http://dx.doi.org/10.1192/bjp.bp.115.177576}},
doi = {{10.1192/bjp.bp.115.177576}},
volume = {{209}},
year = {{2016}},
}