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Intestinal carriage of p fimbriated escherichia coli and the susceptibility to urinary tract infection in young children

Plos, Kaety ; Connell, Hugh LU ; Jodal, Ulf ; Marklund, Britt Inger ; Mårild, Staffan ; Wettergren, Björn and Svanborg, Catharina LU (1995) In Journal of Infectious Diseases 171(3). p.625-631
Abstract

This prospective study analyzed the intestinal carriage of P fimbriated Escherichia coli as a host susceptibility factor in urinary tract infection (UTI). P fimbriation was defined by the pap and G ad hesin (papG1A2prsGJ96)genotypes. Children with UTI carried pap+E. coli in the fecal flora more often than healthy controls both at diagnosis (86% vs. 29%) and during infection-free intervals (40%; P <.01). PI blood group-positive children carried pap+E. col in the fecal flora more often (88%) than those with P2 blood group (40%; P <.05). A pap+E. coli strain caused UTI in 53 of 55 patients who carried both pap+and papstrains in their fecal flora. These... (More)

This prospective study analyzed the intestinal carriage of P fimbriated Escherichia coli as a host susceptibility factor in urinary tract infection (UTI). P fimbriation was defined by the pap and G ad hesin (papG1A2prsGJ96)genotypes. Children with UTI carried pap+E. coli in the fecal flora more often than healthy controls both at diagnosis (86% vs. 29%) and during infection-free intervals (40%; P <.01). PI blood group-positive children carried pap+E. col in the fecal flora more often (88%) than those with P2 blood group (40%; P <.05). A pap+E. coli strain caused UTI in 53 of 55 patients who carried both pap+and papstrains in their fecal flora. These results suggest that persons who develop UTI have an increased tendency to carry pap+E. coli in the large intestine and that these pap+E. coli cause UTI more often than papE. coli strains in the fecal flora of the same host.

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Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
171
issue
3
pages
625 - 631
publisher
Oxford University Press
external identifiers
  • pmid:7876609
  • scopus:0028935257
ISSN
0022-1899
DOI
10.1093/infdis/171.3.625
language
English
LU publication?
yes
id
3d885cd1-9343-49b4-bc67-eee485a383b7
date added to LUP
2019-06-19 14:10:43
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2020-08-30 06:17:33
@article{3d885cd1-9343-49b4-bc67-eee485a383b7,
  abstract     = {<p>This prospective study analyzed the intestinal carriage of P fimbriated Escherichia coli as a host susceptibility factor in urinary tract infection (UTI). P fimbriation was defined by the pap and G ad hesin (papG<sub>1A2</sub>prsG<sub>J96</sub>)genotypes. Children with UTI carried pap<sup>+</sup>E. coli in the fecal flora more often than healthy controls both at diagnosis (86% vs. 29%) and during infection-free intervals (40%; P &lt;.01). PI blood group-positive children carried pap<sup>+</sup>E. col in the fecal flora more often (88%) than those with P2 blood group (40%; P &lt;.05). A pap<sup>+</sup>E. coli strain caused UTI in 53 of 55 patients who carried both pap<sup>+</sup>and pap<sup>–</sup>strains in their fecal flora. These results suggest that persons who develop UTI have an increased tendency to carry pap<sup>+</sup>E. coli in the large intestine and that these pap<sup>+</sup>E. coli cause UTI more often than pap<sup>–</sup>E. coli strains in the fecal flora of the same host.</p>},
  author       = {Plos, Kaety and Connell, Hugh and Jodal, Ulf and Marklund, Britt Inger and Mårild, Staffan and Wettergren, Björn and Svanborg, Catharina},
  issn         = {0022-1899},
  language     = {eng},
  number       = {3},
  pages        = {625--631},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Intestinal carriage of p fimbriated escherichia coli and the susceptibility to urinary tract infection in young children},
  url          = {http://dx.doi.org/10.1093/infdis/171.3.625},
  doi          = {10.1093/infdis/171.3.625},
  volume       = {171},
  year         = {1995},
}