Radiotherapy and neoadjuvant chemotherapy for cervical carcinoma. A randomized multicenter study of sequential cisplatin and 5-fluorouracil and radiotherapy in advanced cervical carcinoma stage 3B and 4A
(1996) In Cancer 77(11). p.2371-2378- Abstract
BACKGROUND: The locoregional failure rate remains high in advanced cervical carcinoma. Chemotherapy (CT) was added to radiotherapy (RT) in order to increase disease control and to improve 5-year survival.
METHODS: CT + RT included cisplatin administered 100mg/m2, d.1 plus 5-fluorouracil 1000 mg/m2 D.1 to 5, ci (120 hrs), q every 3rd week for 3 cycles, followed by RT. RT included external beam irradiation 64.8 Gy in 1.8 Gy fractions, five days a week, by 4-field box technique. The median follow-up was 46 months. Ninety-four patients were evaluable for survival, 47 in the CT + RT group and 47 in the RT group. Ninety-two patients were evaluable for response. Known prognostic factors were equally distributed between the two... (More)
BACKGROUND: The locoregional failure rate remains high in advanced cervical carcinoma. Chemotherapy (CT) was added to radiotherapy (RT) in order to increase disease control and to improve 5-year survival.
METHODS: CT + RT included cisplatin administered 100mg/m2, d.1 plus 5-fluorouracil 1000 mg/m2 D.1 to 5, ci (120 hrs), q every 3rd week for 3 cycles, followed by RT. RT included external beam irradiation 64.8 Gy in 1.8 Gy fractions, five days a week, by 4-field box technique. The median follow-up was 46 months. Ninety-four patients were evaluable for survival, 47 in the CT + RT group and 47 in the RT group. Ninety-two patients were evaluable for response. Known prognostic factors were equally distributed between the two groups.
RESULTS: Of the 43 patients evaluable before RT, 31 (72%) achieved a partial or complete response after CT alone. After RT, 52 patients attained a complete response, 25 in the CT + RT group and 27 in the RT-group. Sixty-three patients developed distant metastases or local relapse, 30 in the CT + RT group and 33 in the RT group. In the CT + RT group 6 of the 9 patients with metastases also had local progression at relapse, in the RT group, 7 of 17 patients. The survival rates for the two groups are not statistically different. Thirty-seven patients are alive, 29 have no evidence of disease. Fifty-seven have died, 29 in the CT + RT group and 28 in the RT group. Fifty-four deaths were related to cancer, and 3 to therapy.
CONCLUSIONS: Sequential CT and RT did not improve the survival, local control, or metastasis rate compared with RT alone.
(Less)
- author
- Sundfør, K ; Tropé, C G ; Högberg, T LU ; Onsrud, M ; Koern, J ; Simonsen, E ; Bertelsen, K and Westberg, R
- publishing date
- 1996-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Carcinoma, Squamous Cell/drug therapy, Chemotherapy, Adjuvant, Cisplatin/administration & dosage, Combined Modality Therapy, Disease Progression, Disease-Free Survival, Drug Administration Schedule, Female, Fluorouracil/administration & dosage, Humans, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local, Prognosis, Radiotherapy, High-Energy/adverse effects, Remission Induction, Survival Analysis, Survival Rate, Treatment Outcome, Uterine Cervical Neoplasms/drug therapy
- in
- Cancer
- volume
- 77
- issue
- 11
- pages
- 2371 - 2378
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8635109
- scopus:0029956050
- ISSN
- 0008-543X
- DOI
- 10.1002/(SICI)1097-0142(19960601)77:11<2371::AID-CNCR28>3.0.CO;2-T
- language
- English
- LU publication?
- no
- id
- 3d923a14-ee8a-432b-a41c-2c201825600c
- date added to LUP
- 2019-09-20 08:03:57
- date last changed
- 2024-01-01 20:55:37
@article{3d923a14-ee8a-432b-a41c-2c201825600c,
abstract = {{<p>BACKGROUND: The locoregional failure rate remains high in advanced cervical carcinoma. Chemotherapy (CT) was added to radiotherapy (RT) in order to increase disease control and to improve 5-year survival.</p><p>METHODS: CT + RT included cisplatin administered 100mg/m2, d.1 plus 5-fluorouracil 1000 mg/m2 D.1 to 5, ci (120 hrs), q every 3rd week for 3 cycles, followed by RT. RT included external beam irradiation 64.8 Gy in 1.8 Gy fractions, five days a week, by 4-field box technique. The median follow-up was 46 months. Ninety-four patients were evaluable for survival, 47 in the CT + RT group and 47 in the RT group. Ninety-two patients were evaluable for response. Known prognostic factors were equally distributed between the two groups.</p><p>RESULTS: Of the 43 patients evaluable before RT, 31 (72%) achieved a partial or complete response after CT alone. After RT, 52 patients attained a complete response, 25 in the CT + RT group and 27 in the RT-group. Sixty-three patients developed distant metastases or local relapse, 30 in the CT + RT group and 33 in the RT group. In the CT + RT group 6 of the 9 patients with metastases also had local progression at relapse, in the RT group, 7 of 17 patients. The survival rates for the two groups are not statistically different. Thirty-seven patients are alive, 29 have no evidence of disease. Fifty-seven have died, 29 in the CT + RT group and 28 in the RT group. Fifty-four deaths were related to cancer, and 3 to therapy.</p><p>CONCLUSIONS: Sequential CT and RT did not improve the survival, local control, or metastasis rate compared with RT alone.</p>}},
author = {{Sundfør, K and Tropé, C G and Högberg, T and Onsrud, M and Koern, J and Simonsen, E and Bertelsen, K and Westberg, R}},
issn = {{0008-543X}},
keywords = {{Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Carcinoma, Squamous Cell/drug therapy; Chemotherapy, Adjuvant; Cisplatin/administration & dosage; Combined Modality Therapy; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil/administration & dosage; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis; Radiotherapy, High-Energy/adverse effects; Remission Induction; Survival Analysis; Survival Rate; Treatment Outcome; Uterine Cervical Neoplasms/drug therapy}},
language = {{eng}},
month = {{06}},
number = {{11}},
pages = {{2371--2378}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Cancer}},
title = {{Radiotherapy and neoadjuvant chemotherapy for cervical carcinoma. A randomized multicenter study of sequential cisplatin and 5-fluorouracil and radiotherapy in advanced cervical carcinoma stage 3B and 4A}},
url = {{http://dx.doi.org/10.1002/(SICI)1097-0142(19960601)77:11<2371::AID-CNCR28>3.0.CO;2-T}},
doi = {{10.1002/(SICI)1097-0142(19960601)77:11<2371::AID-CNCR28>3.0.CO;2-T}},
volume = {{77}},
year = {{1996}},
}