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Psoriasis Triggers and Disease Activity : Analysis of Survey Data from the PSODEEP1 Study

Duvetorp, Albert LU orcid ; Reek, Juul van den ; Wikström, Juni ; Petersen, Magnus Blom ; Zheng, Wenning ; Lysell, Josefin ; Skov, Lone ; Valenzuela, Fernando ; Dyring-Andersen, Beatrice and Eidsmo, Liv (2026) In Acta Dermato-Venereologica 106.
Abstract

Numerous patients with psoriasis will associate disease triggers to changes in disease activity over time. Modern treatments induce remission, but relapse is common if the treatment is stopped. Exploring patients' first-hand experiences is a key starting point to identify triggers that may influence disease relapse. A cross-sectional digital questionnaire was distributed to 2716 individuals with psoriasis in Chile, Denmark, Sweden, and the Netherlands. 71% of participants reported psoriatic disease triggers. Triggers were classified into 24 subgroups dominated by stress (55.3%), infections (17.7%) and alcohol (10.8%). The majority (65%) of the participants experienced seasonal variation in disease activity, and approximately half... (More)

Numerous patients with psoriasis will associate disease triggers to changes in disease activity over time. Modern treatments induce remission, but relapse is common if the treatment is stopped. Exploring patients' first-hand experiences is a key starting point to identify triggers that may influence disease relapse. A cross-sectional digital questionnaire was distributed to 2716 individuals with psoriasis in Chile, Denmark, Sweden, and the Netherlands. 71% of participants reported psoriatic disease triggers. Triggers were classified into 24 subgroups dominated by stress (55.3%), infections (17.7%) and alcohol (10.8%). The majority (65%) of the participants experienced seasonal variation in disease activity, and approximately half reported fluctuating disease activity with periods of flare-ups. The self-reported trigger prevalence varied by gender, disease manifestation (skin psoriasis and/or psoriatic arthritis), and country of residence. The female participants more often reported stress and infections as triggers. Alcohol consumption is more often reported as a trigger in males. Chileans more often reported stress and less frequently reported infections as triggers. Insights into patient-reported disease variations and triggers can be used to aid patient-physician conversations and patient phenotyping during routine clinical practice. Trigger assessment and management could potentially contribute to patient counselling and motivate lifestyle changes.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Female, Male, Cross-Sectional Studies, Psoriasis/epidemiology, Chile/epidemiology, Middle Aged, Alcohol Drinking/adverse effects, Adult, Risk Factors, Sex Factors, Netherlands/epidemiology, Aged, Stress, Psychological/epidemiology, Prevalence, Sweden/epidemiology, Denmark/epidemiology, Recurrence, Seasons, Infections/epidemiology, Young Adult
in
Acta Dermato-Venereologica
volume
106
article number
adv-2025-0167
publisher
Medical Journals Limited
external identifiers
  • pmid:42223410
  • scopus:105040842736
ISSN
1651-2057
DOI
10.2340/actadv.v106.adv-2025-0167
language
English
LU publication?
yes
id
3daf2a47-fa5c-40ca-a019-05e13bab17e5
date added to LUP
2026-06-03 08:55:10
date last changed
2026-08-04 04:01:12
@article{3daf2a47-fa5c-40ca-a019-05e13bab17e5,
  abstract     = {{<p>Numerous patients with psoriasis will associate disease triggers to changes in disease activity over time. Modern treatments induce remission, but relapse is common if the treatment is stopped. Exploring patients' first-hand experiences is a key starting point to identify triggers that may influence disease relapse. A cross-sectional digital questionnaire was distributed to 2716 individuals with psoriasis in Chile, Denmark, Sweden, and the Netherlands. 71% of participants reported psoriatic disease triggers. Triggers were classified into 24 subgroups dominated by stress (55.3%), infections (17.7%) and alcohol (10.8%). The majority (65%) of the participants experienced seasonal variation in disease activity, and approximately half reported fluctuating disease activity with periods of flare-ups. The self-reported trigger prevalence varied by gender, disease manifestation (skin psoriasis and/or psoriatic arthritis), and country of residence. The female participants more often reported stress and infections as triggers. Alcohol consumption is more often reported as a trigger in males. Chileans more often reported stress and less frequently reported infections as triggers. Insights into patient-reported disease variations and triggers can be used to aid patient-physician conversations and patient phenotyping during routine clinical practice. Trigger assessment and management could potentially contribute to patient counselling and motivate lifestyle changes.</p>}},
  author       = {{Duvetorp, Albert and Reek, Juul van den and Wikström, Juni and Petersen, Magnus Blom and Zheng, Wenning and Lysell, Josefin and Skov, Lone and Valenzuela, Fernando and Dyring-Andersen, Beatrice and Eidsmo, Liv}},
  issn         = {{1651-2057}},
  keywords     = {{Humans; Female; Male; Cross-Sectional Studies; Psoriasis/epidemiology; Chile/epidemiology; Middle Aged; Alcohol Drinking/adverse effects; Adult; Risk Factors; Sex Factors; Netherlands/epidemiology; Aged; Stress, Psychological/epidemiology; Prevalence; Sweden/epidemiology; Denmark/epidemiology; Recurrence; Seasons; Infections/epidemiology; Young Adult}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Psoriasis Triggers and Disease Activity : Analysis of Survey Data from the PSODEEP1 Study}},
  url          = {{http://dx.doi.org/10.2340/actadv.v106.adv-2025-0167}},
  doi          = {{10.2340/actadv.v106.adv-2025-0167}},
  volume       = {{106}},
  year         = {{2026}},
}