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Enlargement of the right ventricular outflow tract and the pulmonary artery with a new biodegradable patch in transannular position

Malm, T LU ; Bowald, S ; Bylock, A ; Busch, C and Saldeen, T (1994) In European Surgical Research 26(5). p.298-308
Abstract

Absorbable, nonwoven patches made from polyhydroxybutyrate (PHB) were implanted as transannular patches into the right ventricular outflow tract and pulmonary artery in 13 weanling sheep, the test group. Six sheep, in which a transannular Dacron patch was implanted, served as control group. The test and the control patches were harvested 3-24 months later. The results were documented macroscopically, by histological examination, and by scanning electron microscopy. The 6-keto-PGF1 alpha activity was measured in the regenerated tissue and compared with that in the native pulmonary artery. No aneurysms were noted. Regeneration of a neointima and a neomedia, comparable to native arterial tissue, was observed in the test group. In the... (More)

Absorbable, nonwoven patches made from polyhydroxybutyrate (PHB) were implanted as transannular patches into the right ventricular outflow tract and pulmonary artery in 13 weanling sheep, the test group. Six sheep, in which a transannular Dacron patch was implanted, served as control group. The test and the control patches were harvested 3-24 months later. The results were documented macroscopically, by histological examination, and by scanning electron microscopy. The 6-keto-PGF1 alpha activity was measured in the regenerated tissue and compared with that in the native pulmonary artery. No aneurysms were noted. Regeneration of a neointima and a neomedia, comparable to native arterial tissue, was observed in the test group. In the control group, a neointimal layer was present but no neomedia comparable to native arterial tissue. Scanning electron microscopy disclosed differences in the endothelial structure between the test and control groups. 6-keto-PGF1 alpha activity was present in both the test and control groups. It is concluded that absorbable, nonwoven patches of PHB can be used as a scaffold for tissue regeneration in low-pressure systems. The regenerated vessel had structural and biochemical qualities in common with the native pulmonary artery.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
6-Ketoprostaglandin F1 alpha/analysis, Animals, Cardiac Surgical Procedures/methods, Heart Ventricles/surgery, Hydroxybutyrates, Male, Polyesters, Prostheses and Implants, Pulmonary Artery/surgery, Sheep
in
European Surgical Research
volume
26
issue
5
pages
11 pages
publisher
Karger
external identifiers
  • scopus:0027964383
  • pmid:7835387
ISSN
0014-312X
DOI
10.1159/000129349
language
English
LU publication?
no
id
3db47797-c32e-4ea5-9520-9322f20282a8
date added to LUP
2018-12-05 15:28:36
date last changed
2024-01-15 09:06:59
@article{3db47797-c32e-4ea5-9520-9322f20282a8,
  abstract     = {{<p>Absorbable, nonwoven patches made from polyhydroxybutyrate (PHB) were implanted as transannular patches into the right ventricular outflow tract and pulmonary artery in 13 weanling sheep, the test group. Six sheep, in which a transannular Dacron patch was implanted, served as control group. The test and the control patches were harvested 3-24 months later. The results were documented macroscopically, by histological examination, and by scanning electron microscopy. The 6-keto-PGF1 alpha activity was measured in the regenerated tissue and compared with that in the native pulmonary artery. No aneurysms were noted. Regeneration of a neointima and a neomedia, comparable to native arterial tissue, was observed in the test group. In the control group, a neointimal layer was present but no neomedia comparable to native arterial tissue. Scanning electron microscopy disclosed differences in the endothelial structure between the test and control groups. 6-keto-PGF1 alpha activity was present in both the test and control groups. It is concluded that absorbable, nonwoven patches of PHB can be used as a scaffold for tissue regeneration in low-pressure systems. The regenerated vessel had structural and biochemical qualities in common with the native pulmonary artery.</p>}},
  author       = {{Malm, T and Bowald, S and Bylock, A and Busch, C and Saldeen, T}},
  issn         = {{0014-312X}},
  keywords     = {{6-Ketoprostaglandin F1 alpha/analysis; Animals; Cardiac Surgical Procedures/methods; Heart Ventricles/surgery; Hydroxybutyrates; Male; Polyesters; Prostheses and Implants; Pulmonary Artery/surgery; Sheep}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{298--308}},
  publisher    = {{Karger}},
  series       = {{European Surgical Research}},
  title        = {{Enlargement of the right ventricular outflow tract and the pulmonary artery with a new biodegradable patch in transannular position}},
  url          = {{http://dx.doi.org/10.1159/000129349}},
  doi          = {{10.1159/000129349}},
  volume       = {{26}},
  year         = {{1994}},
}