Difficult cannulation during endoscopic retrograde cholangiopancreatography—needle-knife precut versus transpancreatic sphincterotomy on the basis of successful cannulation and adverse events
Gustafsson, Arvid LU
; Tingstedt, Bobby
LU
and Olsson, Greger
(2024)
In Surgical Endoscopy
- Abstract
Background: When cannulation is challenging during endoscopic retrograde cholangiopancreatography (ERCP), and the standard guidewire technique with sphincterotomy is unsuccessful, alternative cannulation techniques can be used to access the biliary tree. The purpose of this study was to compare the incidence of adverse events and cannulation success rates between transpancreatic sphincterotomy (TPS) and precut sphincterotomy (PCS). Methods: Data from the Swedish Registry for Gallstone Surgery and ERCP (GallRiks), collected from 2011 to 2022, were analyzed. A total of 105,303 ERCP procedures were recorded in GallRiks during the study period. After exclusions, the study population consisted of 47,486 ERCP procedures. Of these, 4547... (More)
Background: When cannulation is challenging during endoscopic retrograde cholangiopancreatography (ERCP), and the standard guidewire technique with sphincterotomy is unsuccessful, alternative cannulation techniques can be used to access the biliary tree. The purpose of this study was to compare the incidence of adverse events and cannulation success rates between transpancreatic sphincterotomy (TPS) and precut sphincterotomy (PCS). Methods: Data from the Swedish Registry for Gallstone Surgery and ERCP (GallRiks), collected from 2011 to 2022, were analyzed. A total of 105,303 ERCP procedures were recorded in GallRiks during the study period. After exclusions, the study population consisted of 47,486 ERCP procedures. Of these, 4547 received PCS and 3273 received TPS. The remaining 39,666 ERCP procedures with conventional sphincterotomy served as the control group. The primary endpoints were successful cannulation and adverse events within 30 days. Results: Successful cannulation was more frequent with the TPS technique than with the PCS technique (86.5% vs. 69.7%), but both groups had a lower cannulation rate than the control group (92.4%; OR-PCS 0.20, 95% CI 0.18–0.21; OR-TPS 0.58, 95% CI 0.52–0.64). The TPS group had a higher incidence of adverse events than the PCS group (24.1% vs. 18.8%) and both groups had a higher incidence of adverse events than the control group (15.5%; OR-PCS 1.25, 95% CI 1.15–1.36; OR-TPS 1.71, 95% CI 1.57–1.87). Adverse events for TPS were driven by a higher incidence of pancreatitis (10.5% vs. 6.4% vs. 4.5%; OR 2.53, 95% CI 2.23–2.86) and perforation (1.6% vs. 0.8% vs. 0.5%; OR 2.99, 95% CI 2.20–4.06) compared to both PCS and control. Conclusion: TPS is more successful at cannulation than PCS; however, this success comes at a higher cost in terms of adverse events, particularly pancreatitis and perforation.
(Less)
- author
- Gustafsson, Arvid
LU
; Tingstedt, Bobby
LU
and Olsson, Greger
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- Adverse events, Endoscopic retrograde cholangiopancreatography, Needle-knife sphincterotomy, Precut sphincterotomy, Transpancreatic sphincterotomy
- in
- Surgical Endoscopy
- publisher
- Springer
- external identifiers
-
- pmid:39739103
- scopus:85213725578
- ISSN
- 0930-2794
- DOI
- 10.1007/s00464-024-11429-y
- language
- English
- LU publication?
- yes
- id
- 3ddf3631-1d91-4e40-a1f6-bb4c8a5b70ae
- date added to LUP
- 2025-03-12 15:02:01
- date last changed
- 2025-07-03 01:21:36
@article{3ddf3631-1d91-4e40-a1f6-bb4c8a5b70ae,
abstract = {{<p>Background: When cannulation is challenging during endoscopic retrograde cholangiopancreatography (ERCP), and the standard guidewire technique with sphincterotomy is unsuccessful, alternative cannulation techniques can be used to access the biliary tree. The purpose of this study was to compare the incidence of adverse events and cannulation success rates between transpancreatic sphincterotomy (TPS) and precut sphincterotomy (PCS). Methods: Data from the Swedish Registry for Gallstone Surgery and ERCP (GallRiks), collected from 2011 to 2022, were analyzed. A total of 105,303 ERCP procedures were recorded in GallRiks during the study period. After exclusions, the study population consisted of 47,486 ERCP procedures. Of these, 4547 received PCS and 3273 received TPS. The remaining 39,666 ERCP procedures with conventional sphincterotomy served as the control group. The primary endpoints were successful cannulation and adverse events within 30 days. Results: Successful cannulation was more frequent with the TPS technique than with the PCS technique (86.5% vs. 69.7%), but both groups had a lower cannulation rate than the control group (92.4%; OR-PCS 0.20, 95% CI 0.18–0.21; OR-TPS 0.58, 95% CI 0.52–0.64). The TPS group had a higher incidence of adverse events than the PCS group (24.1% vs. 18.8%) and both groups had a higher incidence of adverse events than the control group (15.5%; OR-PCS 1.25, 95% CI 1.15–1.36; OR-TPS 1.71, 95% CI 1.57–1.87). Adverse events for TPS were driven by a higher incidence of pancreatitis (10.5% vs. 6.4% vs. 4.5%; OR 2.53, 95% CI 2.23–2.86) and perforation (1.6% vs. 0.8% vs. 0.5%; OR 2.99, 95% CI 2.20–4.06) compared to both PCS and control. Conclusion: TPS is more successful at cannulation than PCS; however, this success comes at a higher cost in terms of adverse events, particularly pancreatitis and perforation.</p>}},
author = {{Gustafsson, Arvid and Tingstedt, Bobby and Olsson, Greger}},
issn = {{0930-2794}},
keywords = {{Adverse events; Endoscopic retrograde cholangiopancreatography; Needle-knife sphincterotomy; Precut sphincterotomy; Transpancreatic sphincterotomy}},
language = {{eng}},
publisher = {{Springer}},
series = {{Surgical Endoscopy}},
title = {{Difficult cannulation during endoscopic retrograde cholangiopancreatography—needle-knife precut versus transpancreatic sphincterotomy on the basis of successful cannulation and adverse events}},
url = {{http://dx.doi.org/10.1007/s00464-024-11429-y}},
doi = {{10.1007/s00464-024-11429-y}},
year = {{2024}},
}