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Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases : A systematic literature review for the 2019 update of EULAR recommendations

Rondaan, Christien ; Furer, Victoria ; Heijstek, Marloes W. ; Agmon-Levin, Nancy ; Bijl, Marc ; Breedveld, Ferdinand C. ; D'Amelio, Raffaele ; Dougados, Maxime ; Kapetanovic, Meliha C. LU and Van Laar, Jacob M. , et al. (2019) In RMD Open 5(2).
Abstract

Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those receiving immunomodulating therapy. Furthermore, a search was performed on the effect of vaccinating household members of patients with AIIRD on the occurrence of vaccine-preventable infections in patients and their household members (including... (More)

Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those receiving immunomodulating therapy. Furthermore, a search was performed on the effect of vaccinating household members of patients with AIIRD on the occurrence of vaccine-preventable infections in patients and their household members (including newborns). The literature search was performed using Medline, Embase and the Cochrane Library (October 2009 to August 2018). Results While most investigated vaccines were efficacious and/or immunogenic in patients with AIIRD, some were less efficacious than in healthy control subjects, and/or in patients receiving immunosuppressive agents. Adverse events of vaccination were generally mild and the rates were comparable to those in healthy persons. Vaccination did not seem to lead to an increase in activity of the underlying AIIRD, but insufficient power of most studies precluded arriving at definite conclusions. The number of studies investigating clinical efficacy of vaccination is still limited. No studies on the effect of vaccinating household members of patients with AIIRD were retrieved. Conclusion Evidence on efficacy, immunogenicity and safety of vaccination in patients with AIIRD was systematically reviewed to provide a basis for updated recommendations.

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published
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keywords
autoimmune diseases, infections, vaccination
in
RMD Open
volume
5
issue
2
article number
e001035
publisher
BMJ Publishing Group
external identifiers
  • scopus:85072164098
ISSN
2056-5933
DOI
10.1136/rmdopen-2019-001035
language
English
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yes
id
3de1761f-dd58-4106-bcf6-37dbb03f9708
date added to LUP
2019-10-02 08:19:59
date last changed
2019-11-20 05:52:44
@article{3de1761f-dd58-4106-bcf6-37dbb03f9708,
  abstract     = {<p>Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those receiving immunomodulating therapy. Furthermore, a search was performed on the effect of vaccinating household members of patients with AIIRD on the occurrence of vaccine-preventable infections in patients and their household members (including newborns). The literature search was performed using Medline, Embase and the Cochrane Library (October 2009 to August 2018). Results While most investigated vaccines were efficacious and/or immunogenic in patients with AIIRD, some were less efficacious than in healthy control subjects, and/or in patients receiving immunosuppressive agents. Adverse events of vaccination were generally mild and the rates were comparable to those in healthy persons. Vaccination did not seem to lead to an increase in activity of the underlying AIIRD, but insufficient power of most studies precluded arriving at definite conclusions. The number of studies investigating clinical efficacy of vaccination is still limited. No studies on the effect of vaccinating household members of patients with AIIRD were retrieved. Conclusion Evidence on efficacy, immunogenicity and safety of vaccination in patients with AIIRD was systematically reviewed to provide a basis for updated recommendations.</p>},
  author       = {Rondaan, Christien and Furer, Victoria and Heijstek, Marloes W. and Agmon-Levin, Nancy and Bijl, Marc and Breedveld, Ferdinand C. and D'Amelio, Raffaele and Dougados, Maxime and Kapetanovic, Meliha C. and Van Laar, Jacob M. and De Thurah, Annette Ladefoged and Landewé, Robert and Molto, Anna and Müller-Ladner, Ulf and Schreiber, Karen and Smolar, Leo and Walker, Jim and Warnatz, Klaus and Wulffraat, Nico M. and Van Assen, Sander and Elkayam, Ori},
  issn         = {2056-5933},
  language     = {eng},
  number       = {2},
  publisher    = {BMJ Publishing Group},
  series       = {RMD Open},
  title        = {Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases : A systematic literature review for the 2019 update of EULAR recommendations},
  url          = {http://dx.doi.org/10.1136/rmdopen-2019-001035},
  doi          = {10.1136/rmdopen-2019-001035},
  volume       = {5},
  year         = {2019},
}