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Biomimetic spinning of artificial spider silk from a chimeric minispidroin

Andersson, Marlene ; Jia, Qiupin ; Abella, Ana ; Lee, Xiau Yeen ; Landreh, Michael ; Purhonen, Pasi ; Hebert, Hans LU ; Tenje, Maria LU ; Robinson, Carol V. and Meng, Qing , et al. (2017) In Nature Chemical Biology 13(3). p.262-264
Abstract

Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Chemical Biology
volume
13
issue
3
pages
3 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:28068309
  • wos:000394431500006
  • scopus:85008658159
ISSN
1552-4450
DOI
10.1038/nchembio.2269
language
English
LU publication?
yes
id
3dedcb1f-bcb4-4b40-ab8d-5b03e1fd553b
date added to LUP
2017-02-27 10:23:44
date last changed
2025-03-04 15:16:10
@article{3dedcb1f-bcb4-4b40-ab8d-5b03e1fd553b,
  abstract     = {{<p>Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.</p>}},
  author       = {{Andersson, Marlene and Jia, Qiupin and Abella, Ana and Lee, Xiau Yeen and Landreh, Michael and Purhonen, Pasi and Hebert, Hans and Tenje, Maria and Robinson, Carol V. and Meng, Qing and Plaza, Gustavo R. and Johansson, Jan and Rising, Anna}},
  issn         = {{1552-4450}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{262--264}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Chemical Biology}},
  title        = {{Biomimetic spinning of artificial spider silk from a chimeric minispidroin}},
  url          = {{http://dx.doi.org/10.1038/nchembio.2269}},
  doi          = {{10.1038/nchembio.2269}},
  volume       = {{13}},
  year         = {{2017}},
}