Psychiatric genetics in the diverse landscape of Latin American populations
(2025) In Nature Genetics 57(5). p.1074-1088- Abstract
- Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review... (More)
- Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics. © Springer Nature America, Inc. 2025. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3e0cbd53-dd12-4290-9c78-e0f404125013
- author
- Bruxel, E.M. ; Ionita-Laza, I. LU and Montalvo-Ortiz, J.L.
- author collaboration
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 57
- issue
- 5
- pages
- 15 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:105002137949
- pmid:40175716
- ISSN
- 1061-4036
- DOI
- 10.1038/s41588-025-02127-z
- language
- English
- LU publication?
- yes
- id
- 3e0cbd53-dd12-4290-9c78-e0f404125013
- date added to LUP
- 2026-03-06 13:09:25
- date last changed
- 2026-03-07 03:00:06
@article{3e0cbd53-dd12-4290-9c78-e0f404125013,
abstract = {{Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics. © Springer Nature America, Inc. 2025.}},
author = {{Bruxel, E.M. and Ionita-Laza, I. and Montalvo-Ortiz, J.L.}},
issn = {{1061-4036}},
language = {{eng}},
number = {{5}},
pages = {{1074--1088}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{Psychiatric genetics in the diverse landscape of Latin American populations}},
url = {{http://dx.doi.org/10.1038/s41588-025-02127-z}},
doi = {{10.1038/s41588-025-02127-z}},
volume = {{57}},
year = {{2025}},
}