Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression
(2020) In Clinical Gerontologist 43(4). p.411-419- Abstract
Objectives: Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late-life depression (LLD). Methods: Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M = 71.9; SD = 6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression severity was measured using the 17-item Hamilton Depression Rating Scale (HDRS; cutoff ≥15). Frailty was assessed using several motor tests. The World Health Organization Disability Assessment Schedule (WHO-DAS) measured disability status. A linear regression analysis was performed to identify relationships of cognition, frailty and depression... (More)
Objectives: Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late-life depression (LLD). Methods: Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M = 71.9; SD = 6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression severity was measured using the 17-item Hamilton Depression Rating Scale (HDRS; cutoff ≥15). Frailty was assessed using several motor tests. The World Health Organization Disability Assessment Schedule (WHO-DAS) measured disability status. A linear regression analysis was performed to identify relationships of cognition, frailty and depression severity with disability. Results: The average number of impaired cognitive tests was 2.0 (SD = 1.9), with 28.2% of participants showing no impaired scores. On average participants reported depression severity of 17.3 (SD = 3.6), and disability total score of 15.1 (SD = 6.9). The regression model accounted for 25.1% of the variance in disability, with only depression severity significantly predicting disability status. Burden of cognitive impairment and frailty were not predictive of disability in this sample. Conclusions: In this sample, only depression severity was associated with increased disability. Clinical Implications: These findings have implications for intervention in LLD, as depression severity may represent a more modifiable risk factor for disability.
(Less)
- author
- Morin, Ruth T. ; Insel, Philip LU ; Bickford, David ; Nelson, Craig and Mackin, R. Scott
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cognitive impairment, disability, frailty, Late life depression
- in
- Clinical Gerontologist
- volume
- 43
- issue
- 4
- pages
- 9 pages
- publisher
- Routledge
- external identifiers
-
- scopus:85076880004
- pmid:31865868
- ISSN
- 0731-7115
- DOI
- 10.1080/07317115.2019.1699882
- language
- English
- LU publication?
- yes
- id
- 3e17e6ab-da0f-4df3-909f-0359e15669a4
- date added to LUP
- 2020-01-10 15:01:27
- date last changed
- 2024-03-20 03:16:17
@article{3e17e6ab-da0f-4df3-909f-0359e15669a4,
abstract = {{<p>Objectives: Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late-life depression (LLD). Methods: Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M = 71.9; SD = 6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression severity was measured using the 17-item Hamilton Depression Rating Scale (HDRS; cutoff ≥15). Frailty was assessed using several motor tests. The World Health Organization Disability Assessment Schedule (WHO-DAS) measured disability status. A linear regression analysis was performed to identify relationships of cognition, frailty and depression severity with disability. Results: The average number of impaired cognitive tests was 2.0 (SD = 1.9), with 28.2% of participants showing no impaired scores. On average participants reported depression severity of 17.3 (SD = 3.6), and disability total score of 15.1 (SD = 6.9). The regression model accounted for 25.1% of the variance in disability, with only depression severity significantly predicting disability status. Burden of cognitive impairment and frailty were not predictive of disability in this sample. Conclusions: In this sample, only depression severity was associated with increased disability. Clinical Implications: These findings have implications for intervention in LLD, as depression severity may represent a more modifiable risk factor for disability.</p>}},
author = {{Morin, Ruth T. and Insel, Philip and Bickford, David and Nelson, Craig and Mackin, R. Scott}},
issn = {{0731-7115}},
keywords = {{cognitive impairment; disability; frailty; Late life depression}},
language = {{eng}},
number = {{4}},
pages = {{411--419}},
publisher = {{Routledge}},
series = {{Clinical Gerontologist}},
title = {{Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression}},
url = {{http://dx.doi.org/10.1080/07317115.2019.1699882}},
doi = {{10.1080/07317115.2019.1699882}},
volume = {{43}},
year = {{2020}},
}