Advanced

Indices of electrical and contractile remodeling during atrial fibrillation in man

Holmqvist, Fredrik LU ; Stridh, Martin LU ; Waktare, Johan E P; Sörnmo, Leif LU ; Roijer, Anders LU and Meurling, Carl LU (2006) In PACE 29(5). p.512-519
Abstract
Atrial electrical and contractile remodeling have been demonstrated to coincide during atrial fibrillation (AF) in experimental studies. We explored whether electrical and contractile remodeling correlate in man and explored its clinical implications. METHODS: Forty-nine patients with persistent AF were studied. Electrical remodeling was assessed noninvasively using spectral analysis to estimate the average fibrillatory rate (AFR). Atrial contractility was assessed by transesophageal echocardiography (TEE) measurement of left atrial appendage outflow velocity (LAAOV). RESULTS: The AFR was 403+/-43 fibrillations per minute (fpm) and the LAAOV was 0.27+/-0.14 m/s. A significant correlation was found between AFR and LAAOV (r=-0.47, P=0.001).... (More)
Atrial electrical and contractile remodeling have been demonstrated to coincide during atrial fibrillation (AF) in experimental studies. We explored whether electrical and contractile remodeling correlate in man and explored its clinical implications. METHODS: Forty-nine patients with persistent AF were studied. Electrical remodeling was assessed noninvasively using spectral analysis to estimate the average fibrillatory rate (AFR). Atrial contractility was assessed by transesophageal echocardiography (TEE) measurement of left atrial appendage outflow velocity (LAAOV). RESULTS: The AFR was 403+/-43 fibrillations per minute (fpm) and the LAAOV was 0.27+/-0.14 m/s. A significant correlation was found between AFR and LAAOV (r=-0.47, P=0.001). In patients with a LAAOV>or=0.25 m/s, the AFR was 387+/-48 fpm compared to 419+/-31 fpm among patients with LAAOV<0.25 m/s (P<0.01). CONCLUSIONS: This study demonstrates that indices of electrical and contractile remodeling are strongly correlated in persistent AF in man. The interindividual overlap, however, is too large to allow predictions of LAAOV based on fibrillatory frequency alone. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PACE
volume
29
issue
5
pages
512 - 519
publisher
Wiley-Blackwell
external identifiers
  • wos:000237353200016
  • pmid:16689848
  • scopus:33646517242
ISSN
1540-8159
DOI
10.1111/j.1540-8159.2006.00386.x
language
English
LU publication?
yes
id
3e57dd62-e42e-4f13-9dd8-7a4bfdf0b8fd (old id 156845)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16689848&dopt=Abstract
date added to LUP
2007-07-05 11:00:34
date last changed
2019-03-08 01:47:27
@article{3e57dd62-e42e-4f13-9dd8-7a4bfdf0b8fd,
  abstract     = {Atrial electrical and contractile remodeling have been demonstrated to coincide during atrial fibrillation (AF) in experimental studies. We explored whether electrical and contractile remodeling correlate in man and explored its clinical implications. METHODS: Forty-nine patients with persistent AF were studied. Electrical remodeling was assessed noninvasively using spectral analysis to estimate the average fibrillatory rate (AFR). Atrial contractility was assessed by transesophageal echocardiography (TEE) measurement of left atrial appendage outflow velocity (LAAOV). RESULTS: The AFR was 403+/-43 fibrillations per minute (fpm) and the LAAOV was 0.27+/-0.14 m/s. A significant correlation was found between AFR and LAAOV (r=-0.47, P=0.001). In patients with a LAAOV&gt;or=0.25 m/s, the AFR was 387+/-48 fpm compared to 419+/-31 fpm among patients with LAAOV&lt;0.25 m/s (P&lt;0.01). CONCLUSIONS: This study demonstrates that indices of electrical and contractile remodeling are strongly correlated in persistent AF in man. The interindividual overlap, however, is too large to allow predictions of LAAOV based on fibrillatory frequency alone.},
  author       = {Holmqvist, Fredrik and Stridh, Martin and Waktare, Johan E P and Sörnmo, Leif and Roijer, Anders and Meurling, Carl},
  issn         = {1540-8159},
  language     = {eng},
  number       = {5},
  pages        = {512--519},
  publisher    = {Wiley-Blackwell},
  series       = {PACE},
  title        = {Indices of electrical and contractile remodeling during atrial fibrillation in man},
  url          = {http://dx.doi.org/10.1111/j.1540-8159.2006.00386.x},
  volume       = {29},
  year         = {2006},
}