PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck
Nylander, K. ; Schildt, E. B. LU ; Eriksson, M. LU
and Roos, Göran
(1997)
In Analytical Cellular Pathology
14.
p.101-110
- Abstract
Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The turnout site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3e815c80-734f-49c9-9d72-74b5fec71b30
- author
- Nylander, K.
; Schildt, E. B.
LU
; Eriksson, M.
LU
and Roos, Göran
- publishing date
- 1997-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- head and neck, Immunohistochemistry, Mutation analysis, Prognosis, Squamous call carcinoma
- in
- Analytical Cellular Pathology
- volume
- 14
- article number
- 591251
- pages
- 101 - 110
- publisher
- IOS Press
- external identifiers
-
- pmid:9313825
- scopus:0030828896
- ISSN
- 0921-8912
- DOI
- 10.1155/1997/591251
- language
- English
- LU publication?
- no
- id
- 3e815c80-734f-49c9-9d72-74b5fec71b30
- date added to LUP
- 2020-02-19 16:02:31
- date last changed
- 2024-10-02 22:05:21
@article{3e815c80-734f-49c9-9d72-74b5fec71b30,
abstract = {{<p>Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The turnout site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.</p>}},
author = {{Nylander, K. and Schildt, E. B. and Eriksson, M. and Roos, Göran}},
issn = {{0921-8912}},
keywords = {{head and neck; Immunohistochemistry; Mutation analysis; Prognosis; Squamous call carcinoma}},
language = {{eng}},
month = {{01}},
pages = {{101--110}},
publisher = {{IOS Press}},
series = {{Analytical Cellular Pathology}},
title = {{PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck}},
url = {{http://dx.doi.org/10.1155/1997/591251}},
doi = {{10.1155/1997/591251}},
volume = {{14}},
year = {{1997}},
}