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Association between uterine artery Doppler blood flow changes and arterial wall elasticity in pregnant women

von Wowern, Emma LU ; Andersson, Jakob; Skarping, Ida Dalene LU ; Howie, Maria Teresa and Olofsson, Per LU (2017) In Journal of Maternal-Fetal and Neonatal Medicine 30(19). p.2309-2314
Abstract

Introduction: Uterine artery (UtA) Doppler velocimetry changes and increased arterial stiffness are associated with preeclampsia. We aimed to investigate the relation between UtA velocimetry changes and arterial stiffness in pregnant women. Methods: Doppler velocimetry and photoplethysmographic digital pulse wave analysis (DPA) were performed in 173 pregnant women in the second or the third trimester, where UtA Doppler pulsatility index (PI), diastolic notching, and UtA score (UAS) combining notching and high PI were calculated. DPA stiffness parameters representing large arteries were ejection elasticity index (EEI) and b/a, small arteries dicrotic index (DI) and d/a, and global stiffness the aging index (AI). Results: One hundred and... (More)

Introduction: Uterine artery (UtA) Doppler velocimetry changes and increased arterial stiffness are associated with preeclampsia. We aimed to investigate the relation between UtA velocimetry changes and arterial stiffness in pregnant women. Methods: Doppler velocimetry and photoplethysmographic digital pulse wave analysis (DPA) were performed in 173 pregnant women in the second or the third trimester, where UtA Doppler pulsatility index (PI), diastolic notching, and UtA score (UAS) combining notching and high PI were calculated. DPA stiffness parameters representing large arteries were ejection elasticity index (EEI) and b/a, small arteries dicrotic index (DI) and d/a, and global stiffness the aging index (AI). Results: One hundred and thirty women had normal Doppler and 43 had diastolic notching, of whom nine had high PI. DI indicated increased stiffness in small arteries when notching was present (p = 0.044) and showed a significant but weak correlation to UAS (p = 0.025, tau 0.12). EEI and b/a indicated increased large artery stiffness (p ≤0.014), d/a small artery stiffness (p = 0.023), and AI a systemic stiffness (p = 0.040) when high PI. Conclusion: High UtA PI was associated with increased systemic arterial stiffness, whereas notching was related to increased stiffness in small arteries only. This indicates pathophysiological differences between the two Doppler parameters.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Arterial stiffness, diastolic notching, photoplethysmography, pregnancy, pulsatility index
in
Journal of Maternal-Fetal and Neonatal Medicine
volume
30
issue
19
pages
6 pages
publisher
Taylor & Francis
external identifiers
  • scopus:84992390442
  • wos:000406757800009
ISSN
1476-7058
DOI
10.1080/14767058.2016.1247264
language
English
LU publication?
yes
id
3e914d49-94fc-48f2-92fa-60a384de160b
date added to LUP
2016-11-08 08:14:55
date last changed
2018-01-07 11:34:07
@article{3e914d49-94fc-48f2-92fa-60a384de160b,
  abstract     = {<p>Introduction: Uterine artery (UtA) Doppler velocimetry changes and increased arterial stiffness are associated with preeclampsia. We aimed to investigate the relation between UtA velocimetry changes and arterial stiffness in pregnant women. Methods: Doppler velocimetry and photoplethysmographic digital pulse wave analysis (DPA) were performed in 173 pregnant women in the second or the third trimester, where UtA Doppler pulsatility index (PI), diastolic notching, and UtA score (UAS) combining notching and high PI were calculated. DPA stiffness parameters representing large arteries were ejection elasticity index (EEI) and b/a, small arteries dicrotic index (DI) and d/a, and global stiffness the aging index (AI). Results: One hundred and thirty women had normal Doppler and 43 had diastolic notching, of whom nine had high PI. DI indicated increased stiffness in small arteries when notching was present (p = 0.044) and showed a significant but weak correlation to UAS (p = 0.025, tau 0.12). EEI and b/a indicated increased large artery stiffness (p ≤0.014), d/a small artery stiffness (p = 0.023), and AI a systemic stiffness (p = 0.040) when high PI. Conclusion: High UtA PI was associated with increased systemic arterial stiffness, whereas notching was related to increased stiffness in small arteries only. This indicates pathophysiological differences between the two Doppler parameters.</p>},
  author       = {von Wowern, Emma and Andersson, Jakob and Skarping, Ida Dalene and Howie, Maria Teresa and Olofsson, Per},
  issn         = {1476-7058},
  keyword      = {Arterial stiffness,diastolic notching,photoplethysmography,pregnancy,pulsatility index},
  language     = {eng},
  number       = {19},
  pages        = {2309--2314},
  publisher    = {Taylor & Francis},
  series       = {Journal of Maternal-Fetal and Neonatal Medicine},
  title        = {Association between uterine artery Doppler blood flow changes and arterial wall elasticity in pregnant women},
  url          = {http://dx.doi.org/10.1080/14767058.2016.1247264},
  volume       = {30},
  year         = {2017},
}