Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation
(2011) In Brain Injury 25(1). p.113-126- Abstract
- Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results:... (More)
- Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-alpha, IL-6 and IL-1 beta levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group. Conclusion: The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1868604
- author
- Kara, Ihsan ; Nurten, Asiye ; Aydin, Makbule ; Ozkok, Elif ; Ozen, Ilknur LU ; Ozerman, Bilge ; Tuna, Sevilcan and Karamursel, Sacit
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- EEG, ischemia/reperfusion, oxidative stress, inflammation, polyphenols
- in
- Brain Injury
- volume
- 25
- issue
- 1
- pages
- 113 - 126
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000288101700012
- scopus:78650208570
- pmid:21117911
- ISSN
- 1362-301X
- DOI
- 10.3109/02699052.2010.531688
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 3e9fe838-1d28-4bde-8121-0d865e22b479 (old id 1868604)
- date added to LUP
- 2016-04-01 10:11:53
- date last changed
- 2022-01-25 20:48:11
@article{3e9fe838-1d28-4bde-8121-0d865e22b479, abstract = {{Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-alpha, IL-6 and IL-1 beta levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group. Conclusion: The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia.}}, author = {{Kara, Ihsan and Nurten, Asiye and Aydin, Makbule and Ozkok, Elif and Ozen, Ilknur and Ozerman, Bilge and Tuna, Sevilcan and Karamursel, Sacit}}, issn = {{1362-301X}}, keywords = {{EEG; ischemia/reperfusion; oxidative stress; inflammation; polyphenols}}, language = {{eng}}, number = {{1}}, pages = {{113--126}}, publisher = {{Taylor & Francis}}, series = {{Brain Injury}}, title = {{Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation}}, url = {{http://dx.doi.org/10.3109/02699052.2010.531688}}, doi = {{10.3109/02699052.2010.531688}}, volume = {{25}}, year = {{2011}}, }