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Burden of Diarrhea in the Eastern Mediterranean Region, 1990-2013 : Findings from the Global Burden of Disease Study 2013

Khalil, Ibrahim; Colombara, Danny V; Forouzanfar, Mohammad Hossein; Troeger, Christopher; Daoud, Farah; Moradi-Lakeh, Maziar; Bcheraoui, Charbel El; Rao, Puja C; Afshin, Ashkan and Charara, Raghid, et al. (2016) In American Journal of Tropical Medicine and Hygiene 95(6). p.1319-1329
Abstract

Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths (3.6% of total deaths) were due to DD in the EMR in 2013, with a greater burden... (More)

Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths (3.6% of total deaths) were due to DD in the EMR in 2013, with a greater burden of DD in low- and middle-income countries. Diarrhea deaths per 100,000 children under 5 years of age ranged from one (95% uncertainty interval [UI] = 0-1) in Bahrain and Oman to 471 (95% UI = 245-763) in Somalia. The pattern for diarrhea DALYs among those under 5 years of age closely followed that for diarrheal deaths. DALYs per 100,000 ranged from 739 (95% UI = 520-989) in Syria to 40,869 (95% UI = 21,540-65,823) in Somalia. Our results highlighted a highly inequitable burden of DD in EMR, mainly driven by the lack of access to proper resources such as water and sanitation. Our findings will guide preventive and treatment interventions which are based on evidence and which follow the ultimate goal of reducing the DD burden.

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published
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American Journal of Tropical Medicine and Hygiene
volume
95
issue
6
pages
1319 - 1329
publisher
AMER SOC TROP MED & HYGIENE
external identifiers
  • scopus:85005950002
  • wos:000400206900017
ISSN
1476-1645
DOI
10.4269/ajtmh.16-0339
language
English
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yes
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3ea3f191-be64-4c99-a95a-fe1f863813a9
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2016-12-13 13:26:58
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2017-09-18 11:31:13
@article{3ea3f191-be64-4c99-a95a-fe1f863813a9,
  abstract     = {<p>Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths (3.6% of total deaths) were due to DD in the EMR in 2013, with a greater burden of DD in low- and middle-income countries. Diarrhea deaths per 100,000 children under 5 years of age ranged from one (95% uncertainty interval [UI] = 0-1) in Bahrain and Oman to 471 (95% UI = 245-763) in Somalia. The pattern for diarrhea DALYs among those under 5 years of age closely followed that for diarrheal deaths. DALYs per 100,000 ranged from 739 (95% UI = 520-989) in Syria to 40,869 (95% UI = 21,540-65,823) in Somalia. Our results highlighted a highly inequitable burden of DD in EMR, mainly driven by the lack of access to proper resources such as water and sanitation. Our findings will guide preventive and treatment interventions which are based on evidence and which follow the ultimate goal of reducing the DD burden.</p>},
  author       = {Khalil, Ibrahim and Colombara, Danny V and Forouzanfar, Mohammad Hossein and Troeger, Christopher and Daoud, Farah and Moradi-Lakeh, Maziar and Bcheraoui, Charbel El and Rao, Puja C and Afshin, Ashkan and Charara, Raghid and Abate, Kalkidan Hassen and Razek, Mohammed Magdy Abd El and Abd-Allah, Foad and Abu-Elyazeed, Remon and Kiadaliri, Aliasghar Ahmad and Akanda, Ali Shafqat and Akseer, Nadia and Alam, Khurshid and Alasfoor, Deena and Ali, Raghib and AlMazroa, Mohammad A and Alomari, Mahmoud A and Al-Raddadi, Rajaa Mohammad Salem and Alsharif, Ubai and Alsowaidi, Shirina and Altirkawi, Khalid A and Alvis-Guzman, Nelson and Ammar, Walid and Antonio, Carl Abelardo T and Asayesh, Hamid and Asghar, Rana Jawad and Atique, Suleman and Awasthi, Ashish and Bacha, Umar and Badawi, Alaa and Barac, Aleksandra and Bedi, Neeraj and Bekele, Tolesa and Bensenor, Isabela M and Betsu, Balem Demtsu and Bhutta, Zulfiqar and Abdulhak, Aref A Bin and Butt, Zahid A and Danawi, Hadi and Dubey, Manisha and Endries, Aman Yesuf and Faghmous, Imad D A and Farid, Talha and Farvid, Maryam S and Farzadfar, Farshad and Fereshtehnejad, Seyed-Mohammad and Fischer, Florian and Fitchett, Joseph Robert Anderson and Gibney, Katherine B and Ginawi, Ibrahim Abdelmageem Mohamed and Gishu, Melkamu Dedefo and Gugnani, Harish Chander and Gupta, Rahul and Hailu, Gessessew Bugssa and Hamadeh, Randah Ribhi and Hamidi, Samer and Harb, Hilda L and Hedayati, Mohammad T and Hsairi, Mohamed and Husseini, Abdullatif and Jahanmehr, Nader and Javanbakht, Mehdi and Jibat, Tariku and Jonas, Jost B and Kasaeian, Amir and Khader, Yousef Saleh and Khan, Abdur Rahman and Khan, Ejaz Ahmad and Khan, Gulfaraz and Khoja, Tawfik Ahmed Muthafer and Kinfu, Yohannes and Kissoon, Niranjan and Koyanagi, Ai and Lal, Aparna and Latif, Asma Abdul Abdul and Lunevicius, Raimundas and Razek, Hassan Magdy Abd El and Majeed, Azeem and Malekzadeh, Reza and Mehari, Alem and Mekonnen, Alemayehu B and Melaku, Yohannes Adama and Memish, Ziad A and Mendoza, Walter and Misganaw, Awoke and Mohamed, Layla Abdalla Ibrahim and Nachega, Jean B and Nguyen, Quyen Le and Nisar, Muhammad Imran and Peprah, Emmanuel Kwame and Platts-Mills, James A and Pourmalek, Farshad and Qorbani, Mostafa and Rafay, Anwar and Rahimi-Movaghar, Vafa and Rahman, Sajjad Ur and Rai, Rajesh Kumar and Rana, Saleem M and Ranabhat, Chhabi L and Rao, Sowmya R and Refaat, Amany H and Riddle, Mark and Roshandel, Gholamreza and Ruhago, George Mugambage and Saleh, Muhammad Muhammad and Sanabria, Juan R and Sawhney, Monika and Sepanlou, Sadaf G and Setegn, Tesfaye and Sliwa, Karen and Sreeramareddy, Chandrashekhar T and Sykes, Bryan L and Tavakkoli, Mohammad and Tedla, Bemnet Amare and Terkawi, Abdullah S and Ukwaja, Kingsley and Uthman, Olalekan A and Westerman, Ronny and Wubshet, Mamo and Yenesew, Muluken A and Yonemoto, Naohiro and Younis, Mustafa Z and Zaidi, Zoubida and Zaki, Maysaa El Sayed and Rabeeah, Abdullah A Al and Wang, Haidong and Naghavi, Mohsen and Vos, Theo and Lopez, Alan D and Murray, Christopher J L and Mokdad, Ali H},
  issn         = {1476-1645},
  language     = {eng},
  month        = {10},
  number       = {6},
  pages        = {1319--1329},
  publisher    = {AMER SOC TROP MED & HYGIENE},
  series       = {American Journal of Tropical Medicine and Hygiene},
  title        = {Burden of Diarrhea in the Eastern Mediterranean Region, 1990-2013 : Findings from the Global Burden of Disease Study 2013},
  url          = {http://dx.doi.org/10.4269/ajtmh.16-0339},
  volume       = {95},
  year         = {2016},
}