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A model of protein interactions for regulating plant stem cells

Gruel, Jérémy LU ; Deichmann, Julia ; Landrein, Benoit ; Hitchcock, Thomas and Jönsson, Henrik LU (2017) In bioRxiv
Abstract
The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory ‘pocket’ surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression... (More)
The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory ‘pocket’ surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker CLAVATA3 and its activator WUSCHEL is achieved, and recent findings of plasticity in the system.
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publication status
published
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in
bioRxiv
pages
33 pages
publisher
bioRxiv
DOI
10.1101/237933
language
English
LU publication?
yes
id
3ecf7e17-a12d-4359-90a4-c0ef9f1c3ad4
date added to LUP
2019-07-31 16:55:53
date last changed
2021-12-03 13:50:24
@misc{3ecf7e17-a12d-4359-90a4-c0ef9f1c3ad4,
  abstract     = {{The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory ‘pocket’ surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker <i>CLAVATA3</i> and its activator <i>WUSCHEL</i> is achieved, and recent findings of plasticity in the system.<br/>}},
  author       = {{Gruel, Jérémy and Deichmann, Julia and Landrein, Benoit and Hitchcock, Thomas and Jönsson, Henrik}},
  language     = {{eng}},
  publisher    = {{bioRxiv}},
  series       = {{bioRxiv}},
  title        = {{A model of protein interactions for regulating plant stem cells}},
  url          = {{http://dx.doi.org/10.1101/237933}},
  doi          = {{10.1101/237933}},
  year         = {{2017}},
}