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Prognostic Impact of Chronic Total Occlusions : A Report From SCAAR (Swedish Coronary Angiography and Angioplasty Registry)

Råmunddal, Truls ; Hoebers, Loes P. ; Henriques, José P S ; Dworeck, Christian ; Angerås, Oskar ; Odenstedt, Jacob ; Ioanes, Dan ; Olivecrona, Göran LU ; Harnek, Jan LU and Jensen, Ulf , et al. (2016) In JACC: Cardiovascular Interventions 9(15). p.1535-1544
Abstract

Objectives The aim of this study was to determine the prognostic impact of chronic total occlusion (CTO) on long-term mortality in a large prospective cohort. Background CTO is present in many patients with coronary artery disease and is difficult to treat with percutaneous coronary intervention. Methods The study population consisted of all consecutive patients who underwent coronary angiography in Sweden between January 1, 2005 and January 1, 2012, who were registered in SCAAR (Swedish Coronary Angiography and Angioplasty Registry). The patient population was heterogeneous with regard to indication for angiography (stable angina, ST-segment elevation myocardial infarction [STEMI], unstable angina or non-STEMI, and other) and treatment... (More)

Objectives The aim of this study was to determine the prognostic impact of chronic total occlusion (CTO) on long-term mortality in a large prospective cohort. Background CTO is present in many patients with coronary artery disease and is difficult to treat with percutaneous coronary intervention. Methods The study population consisted of all consecutive patients who underwent coronary angiography in Sweden between January 1, 2005 and January 1, 2012, who were registered in SCAAR (Swedish Coronary Angiography and Angioplasty Registry). The patient population was heterogeneous with regard to indication for angiography (stable angina, ST-segment elevation myocardial infarction [STEMI], unstable angina or non-STEMI, and other) and treatment options. The long-term mortality rates of patients with and without CTO were compared by using shared frailty Cox proportional hazards regression adjusted for confounders. Tests were conducted for interactions between CTO and several pre-specified characteristics: indication for angiography and percutaneous coronary intervention (stable angina, STEMI, unstable angina or non-STEMI, and other), severity of coronary artery disease (1-, 2-, and 3-vessel and/or left main coronary artery disease), age, sex, and diabetes. Results During the study period, 14,441 patients with CTO and 75,431 patients without CTO were registered in SCAAR. CTO was associated with higher mortality (hazard ratio: 1.29; 95% confidence interval: 1.22 to 1.37; p < 0.001). In subgroup analyses, the risk attributable to CTO was lowest in patients with stable angina and highest in those with STEMI. In addition, CTO was associated with highest risk in patients under 60 years of age and with lowest risk in octogenarians. There was no interaction between CTO and either diabetes or sex, suggesting an equally adverse effect in both groups. Conclusions In this large prospective observational study of patients with coronary artery disease, CTO was associated with increased mortality. This association was most prominent in younger patients and in those with acute coronary syndromes.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute coronary syndrome(s), chronic total occlusion, coronary artery disease, percutaneous coronary intervention, SCAAR
in
JACC: Cardiovascular Interventions
volume
9
issue
15
pages
10 pages
publisher
Elsevier
external identifiers
  • pmid:27491603
  • wos:000381745600007
  • scopus:84992144610
ISSN
1936-8798
DOI
10.1016/j.jcin.2016.04.031
language
English
LU publication?
yes
id
3ed75363-b5dd-4964-abd7-cf2adf1b9b9e
date added to LUP
2016-11-04 10:54:37
date last changed
2025-02-08 17:18:41
@article{3ed75363-b5dd-4964-abd7-cf2adf1b9b9e,
  abstract     = {{<p>Objectives The aim of this study was to determine the prognostic impact of chronic total occlusion (CTO) on long-term mortality in a large prospective cohort. Background CTO is present in many patients with coronary artery disease and is difficult to treat with percutaneous coronary intervention. Methods The study population consisted of all consecutive patients who underwent coronary angiography in Sweden between January 1, 2005 and January 1, 2012, who were registered in SCAAR (Swedish Coronary Angiography and Angioplasty Registry). The patient population was heterogeneous with regard to indication for angiography (stable angina, ST-segment elevation myocardial infarction [STEMI], unstable angina or non-STEMI, and other) and treatment options. The long-term mortality rates of patients with and without CTO were compared by using shared frailty Cox proportional hazards regression adjusted for confounders. Tests were conducted for interactions between CTO and several pre-specified characteristics: indication for angiography and percutaneous coronary intervention (stable angina, STEMI, unstable angina or non-STEMI, and other), severity of coronary artery disease (1-, 2-, and 3-vessel and/or left main coronary artery disease), age, sex, and diabetes. Results During the study period, 14,441 patients with CTO and 75,431 patients without CTO were registered in SCAAR. CTO was associated with higher mortality (hazard ratio: 1.29; 95% confidence interval: 1.22 to 1.37; p &lt; 0.001). In subgroup analyses, the risk attributable to CTO was lowest in patients with stable angina and highest in those with STEMI. In addition, CTO was associated with highest risk in patients under 60 years of age and with lowest risk in octogenarians. There was no interaction between CTO and either diabetes or sex, suggesting an equally adverse effect in both groups. Conclusions In this large prospective observational study of patients with coronary artery disease, CTO was associated with increased mortality. This association was most prominent in younger patients and in those with acute coronary syndromes.</p>}},
  author       = {{Råmunddal, Truls and Hoebers, Loes P. and Henriques, José P S and Dworeck, Christian and Angerås, Oskar and Odenstedt, Jacob and Ioanes, Dan and Olivecrona, Göran and Harnek, Jan and Jensen, Ulf and Aasa, Mikael and Albertsson, Per and Wedel, Hans and Omerovic, Elmir}},
  issn         = {{1936-8798}},
  keywords     = {{acute coronary syndrome(s); chronic total occlusion; coronary artery disease; percutaneous coronary intervention; SCAAR}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{15}},
  pages        = {{1535--1544}},
  publisher    = {{Elsevier}},
  series       = {{JACC: Cardiovascular Interventions}},
  title        = {{Prognostic Impact of Chronic Total Occlusions : A Report From SCAAR (Swedish Coronary Angiography and Angioplasty Registry)}},
  url          = {{http://dx.doi.org/10.1016/j.jcin.2016.04.031}},
  doi          = {{10.1016/j.jcin.2016.04.031}},
  volume       = {{9}},
  year         = {{2016}},
}