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Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals

Siino, Valentina LU ; Ali, Ashfaq LU orcid ; Accardi, Giulia ; Aiello, Anna ; Ligotti, Mattia E. ; Mosquim Junior, Sergio LU orcid ; Candore, Giuseppina ; Caruso, Calogero ; Levander, Fredrik LU orcid and Vasto, Sonya (2022) In Aging Cell 21(9).
Abstract

The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aging, longevity, plasma proteome
in
Aging Cell
volume
21
issue
9
article number
e13684
publisher
Wiley-Blackwell
external identifiers
  • pmid:35932462
  • scopus:85135527650
ISSN
1474-9718
DOI
10.1111/acel.13684
language
English
LU publication?
yes
id
3edb41bf-23dd-4982-9d23-2f72c755e56c
date added to LUP
2022-10-11 12:49:44
date last changed
2025-10-18 22:54:11
@article{3edb41bf-23dd-4982-9d23-2f72c755e56c,
  abstract     = {{<p>The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.</p>}},
  author       = {{Siino, Valentina and Ali, Ashfaq and Accardi, Giulia and Aiello, Anna and Ligotti, Mattia E. and Mosquim Junior, Sergio and Candore, Giuseppina and Caruso, Calogero and Levander, Fredrik and Vasto, Sonya}},
  issn         = {{1474-9718}},
  keywords     = {{aging; longevity; plasma proteome}},
  language     = {{eng}},
  number       = {{9}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Aging Cell}},
  title        = {{Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals}},
  url          = {{http://dx.doi.org/10.1111/acel.13684}},
  doi          = {{10.1111/acel.13684}},
  volume       = {{21}},
  year         = {{2022}},
}