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Perivascular Neurotransmitter Regulation of Cerebral Blood Flow

Edvinsson, L. LU (2017) In Primer on Cerebrovascular Diseases: Second Edition p.70-74
Abstract

Cerebral circulation is regulated by two principal systems: autonomic and sensory nerves from cranial ganglia and intrinsic innervation of the cerebral microcirculation. The sympathetic innervation originates from the superior cervical ganglion and stores noradrenaline and neuropeptide Y. It has a role in the extreme limits of the autoregulation. The parasympathetic innervation of the brain circulation originates in the sphenopalatine and otic ganglia. This system stores acetylcholine, vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and nitric oxide synthase (NOS). The sensory fibers, involved in cranial pain syndromes, originates in the trigeminal ganglion and stores calcitonin gene-related peptide,... (More)

Cerebral circulation is regulated by two principal systems: autonomic and sensory nerves from cranial ganglia and intrinsic innervation of the cerebral microcirculation. The sympathetic innervation originates from the superior cervical ganglion and stores noradrenaline and neuropeptide Y. It has a role in the extreme limits of the autoregulation. The parasympathetic innervation of the brain circulation originates in the sphenopalatine and otic ganglia. This system stores acetylcholine, vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and nitric oxide synthase (NOS). The sensory fibers, involved in cranial pain syndromes, originates in the trigeminal ganglion and stores calcitonin gene-related peptide, substance P, neurokinin A, NOS, and nociceptin, inter alia. Besides these, the intracerebral microcirculation (small arterioles, capillaries, and venules) forms, with the surrounding glial cells and intracerebral neurons, a neurovascular unit that may regulate the cerebral microcirculation.

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Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Autonomic nerves, Intrinsic innervation, Parasympathetic, Perivascular nerves, Sensory nerves, Sympathetic
in
Primer on Cerebrovascular Diseases: Second Edition
pages
5 pages
publisher
Elsevier Inc.
external identifiers
  • scopus:85028292294
ISBN
9780128030585
DOI
10.1016/B978-0-12-803058-5.00013-8
language
English
LU publication?
no
id
3ee47813-b703-466c-a386-5cfdbe6a0c32
date added to LUP
2017-09-08 08:00:02
date last changed
2018-01-07 12:18:30
@inbook{3ee47813-b703-466c-a386-5cfdbe6a0c32,
  abstract     = {<p>Cerebral circulation is regulated by two principal systems: autonomic and sensory nerves from cranial ganglia and intrinsic innervation of the cerebral microcirculation. The sympathetic innervation originates from the superior cervical ganglion and stores noradrenaline and neuropeptide Y. It has a role in the extreme limits of the autoregulation. The parasympathetic innervation of the brain circulation originates in the sphenopalatine and otic ganglia. This system stores acetylcholine, vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and nitric oxide synthase (NOS). The sensory fibers, involved in cranial pain syndromes, originates in the trigeminal ganglion and stores calcitonin gene-related peptide, substance P, neurokinin A, NOS, and nociceptin, inter alia. Besides these, the intracerebral microcirculation (small arterioles, capillaries, and venules) forms, with the surrounding glial cells and intracerebral neurons, a neurovascular unit that may regulate the cerebral microcirculation.</p>},
  author       = {Edvinsson, L.},
  isbn         = {9780128030585},
  keyword      = {Autonomic nerves,Intrinsic innervation,Parasympathetic,Perivascular nerves,Sensory nerves,Sympathetic},
  language     = {eng},
  month        = {03},
  pages        = {70--74},
  publisher    = {Elsevier Inc.},
  series       = {Primer on Cerebrovascular Diseases: Second Edition},
  title        = {Perivascular Neurotransmitter Regulation of Cerebral Blood Flow},
  url          = {http://dx.doi.org/10.1016/B978-0-12-803058-5.00013-8},
  year         = {2017},
}