Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Leijenaar, Jolien F. ; Groot, Colin ; Sudre, Carole H. ; Bergeron, David ; Leeuwis, Anna E. ; Cardoso, M. Jorge ; Carrasco, Ferran Prados ; Laforce, Robert ; Barkhof, Frederik and van der Flier, Wiesje M. , et al. (2020) In Alzheimer's and Dementia 16(2). p.354-364
Abstract

Introduction: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ− mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ− major-VCD (n = 35). We measured depression with the Geriatric Depression Scale, cognition with a neuropsychological test battery and derived white matter hyperintensities (WMH) and gray matter atrophy from MRI. Results: Aβ− patients showed more depressive symptoms than Aβ+. In the major-VCD group, Aβ− patients performed worse on attention (P =.02) and executive functioning (P =.008)... (More)

Introduction: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ42 levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ− mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ− major-VCD (n = 35). We measured depression with the Geriatric Depression Scale, cognition with a neuropsychological test battery and derived white matter hyperintensities (WMH) and gray matter atrophy from MRI. Results: Aβ− patients showed more depressive symptoms than Aβ+. In the major-VCD group, Aβ− patients performed worse on attention (P =.02) and executive functioning (P =.008) than Aβ+. We found no cognitive differences in patients with mild VCD. In the mild-VCD group, Aβ− patients had more WMH than Aβ+ patients, whereas conversely, in the major-VCD group, Aβ+ patients had more WMH. Atrophy patterns did not differ between Aβ+ and Aβ− VCD group. Discussion: Comorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amyloid-β, Cognition, Gray matter atrophy, MRI, Vascular cognitive disorders, Vascular dementia, White matter hyperintensities
in
Alzheimer's and Dementia
volume
16
issue
2
pages
11 pages
publisher
Wiley
external identifiers
  • pmid:31786129
  • scopus:85075884847
ISSN
1552-5260
DOI
10.1016/j.jalz.2019.08.190
language
English
LU publication?
yes
id
3eed47f0-80d8-4a18-bb0b-8e989452a52f
date added to LUP
2021-01-13 12:30:02
date last changed
2024-03-05 18:47:17
@article{3eed47f0-80d8-4a18-bb0b-8e989452a52f,
  abstract     = {{<p>Introduction: To date, the clinical relevance of comorbid amyloid-β (Aβ) pathology in patients with vascular cognitive disorders (VCD) is largely unknown. Methods: We included 218 VCD patients with available cerebrospinal fluid Aβ<sub>42</sub> levels. Patients were divided into Aβ+ mild-VCD (n = 84), Aβ− mild-VCD (n = 68), Aβ+ major-VCD (n = 31), and Aβ− major-VCD (n = 35). We measured depression with the Geriatric Depression Scale, cognition with a neuropsychological test battery and derived white matter hyperintensities (WMH) and gray matter atrophy from MRI. Results: Aβ− patients showed more depressive symptoms than Aβ+. In the major-VCD group, Aβ− patients performed worse on attention (P =.02) and executive functioning (P =.008) than Aβ+. We found no cognitive differences in patients with mild VCD. In the mild-VCD group, Aβ− patients had more WMH than Aβ+ patients, whereas conversely, in the major-VCD group, Aβ+ patients had more WMH. Atrophy patterns did not differ between Aβ+ and Aβ− VCD group. Discussion: Comorbid Aβ pathology affects the manifestation of VCD, but effects differ by severity of VCD.</p>}},
  author       = {{Leijenaar, Jolien F. and Groot, Colin and Sudre, Carole H. and Bergeron, David and Leeuwis, Anna E. and Cardoso, M. Jorge and Carrasco, Ferran Prados and Laforce, Robert and Barkhof, Frederik and van der Flier, Wiesje M. and Scheltens, Philip and Prins, Niels D. and Ossenkoppele, Rik}},
  issn         = {{1552-5260}},
  keywords     = {{Amyloid-β; Cognition; Gray matter atrophy; MRI; Vascular cognitive disorders; Vascular dementia; White matter hyperintensities}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{354--364}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Comorbid amyloid-β pathology affects clinical and imaging features in VCD}},
  url          = {{http://dx.doi.org/10.1016/j.jalz.2019.08.190}},
  doi          = {{10.1016/j.jalz.2019.08.190}},
  volume       = {{16}},
  year         = {{2020}},
}