Development of an All-Marine 3D Printed Bioactive Hydrogel Dressing for Treatment of Hard-to-Heal Wounds
(2023) In Polymers 15(12).- Abstract
Current standard wound care involves dressings that provide moisture and protection; however, dressings providing active healing are still scarce and expensive. We aimed to develop an ecologically sustainable 3D printed bioactive hydrogel-based topical wound dressing targeting healing of hard-to-heal wounds, such as chronic or burn wounds, which are low on exudate. To this end, we developed a formulation composed of renewable marine components; purified extract from unfertilized salmon roe (heat-treated X, HTX), alginate from brown seaweed, and nanocellulose from tunicates. HTX is believed to facilitate the wound healing process. The components were successfully formulated into a 3D printable ink that was used to create a hydrogel... (More)
Current standard wound care involves dressings that provide moisture and protection; however, dressings providing active healing are still scarce and expensive. We aimed to develop an ecologically sustainable 3D printed bioactive hydrogel-based topical wound dressing targeting healing of hard-to-heal wounds, such as chronic or burn wounds, which are low on exudate. To this end, we developed a formulation composed of renewable marine components; purified extract from unfertilized salmon roe (heat-treated X, HTX), alginate from brown seaweed, and nanocellulose from tunicates. HTX is believed to facilitate the wound healing process. The components were successfully formulated into a 3D printable ink that was used to create a hydrogel lattice structure. The 3D printed hydrogel showed a HTX release profile enhancing pro-collagen I alpha 1 production in cell culture with potential of promoting wound closure rates. The dressing has recently been tested on burn wounds in Göttingen minipigs and shows accelerated wound closure and reduced inflammation. This paper describes the dressings development, mechanical properties, bioactivity, and safety.
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- author
- Stenlund, Patrik ; Enstedt, Linnea ; Gilljam, Karin Margaretha ; Standoft, Simon ; Ahlinder, Astrid ; Lundin Johnson, Maria ; Lund, Henrik ; Millqvist Fureby, Anna LU and Berglin, Mattias
- publishing date
- 2023-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 3D printed scaffolds, alginate, biomaterial, hard-to-heal wounds, nanocellulose, salmon roe, wound dressing
- in
- Polymers
- volume
- 15
- issue
- 12
- article number
- 2627
- pages
- 16 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85163772755
- ISSN
- 2073-4360
- DOI
- 10.3390/polym15122627
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2023 by the authors.
- id
- 3f0668e3-5a8f-4bfa-bb41-080eb589f71f
- date added to LUP
- 2025-03-21 09:48:40
- date last changed
- 2025-03-21 14:49:03
@article{3f0668e3-5a8f-4bfa-bb41-080eb589f71f,
abstract = {{<p>Current standard wound care involves dressings that provide moisture and protection; however, dressings providing active healing are still scarce and expensive. We aimed to develop an ecologically sustainable 3D printed bioactive hydrogel-based topical wound dressing targeting healing of hard-to-heal wounds, such as chronic or burn wounds, which are low on exudate. To this end, we developed a formulation composed of renewable marine components; purified extract from unfertilized salmon roe (heat-treated X, HTX), alginate from brown seaweed, and nanocellulose from tunicates. HTX is believed to facilitate the wound healing process. The components were successfully formulated into a 3D printable ink that was used to create a hydrogel lattice structure. The 3D printed hydrogel showed a HTX release profile enhancing pro-collagen I alpha 1 production in cell culture with potential of promoting wound closure rates. The dressing has recently been tested on burn wounds in Göttingen minipigs and shows accelerated wound closure and reduced inflammation. This paper describes the dressings development, mechanical properties, bioactivity, and safety.</p>}},
author = {{Stenlund, Patrik and Enstedt, Linnea and Gilljam, Karin Margaretha and Standoft, Simon and Ahlinder, Astrid and Lundin Johnson, Maria and Lund, Henrik and Millqvist Fureby, Anna and Berglin, Mattias}},
issn = {{2073-4360}},
keywords = {{3D printed scaffolds; alginate; biomaterial; hard-to-heal wounds; nanocellulose; salmon roe; wound dressing}},
language = {{eng}},
number = {{12}},
publisher = {{MDPI AG}},
series = {{Polymers}},
title = {{Development of an All-Marine 3D Printed Bioactive Hydrogel Dressing for Treatment of Hard-to-Heal Wounds}},
url = {{http://dx.doi.org/10.3390/polym15122627}},
doi = {{10.3390/polym15122627}},
volume = {{15}},
year = {{2023}},
}