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APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

Lagging, Cecilia ; Lorentzen, Erik ; Stanne, Tara M. ; Pedersen, Annie ; Söderholm, Martin LU ; Cole, John W. ; Jood, Katarina ; Lemmens, Robin ; Phuah, Chia Ling and Rost, Natalia S. , et al. (2019) In Neurology 93(19). p.849-853
Abstract
Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.

The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with... (More)
Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.

The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with APOE alleles are not directly captured in a regular genome-wide association study (GWAS), where each SNP is investigated separately. We derived the 3 common APOE alleles and investigated the interplay between APOE, age at ischemic stroke onset, severity, sex, and outcome within a large international collaboration, the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network. (Less)
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published
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Neurology
volume
93
issue
19
pages
5 pages
publisher
American Academy of Neurology
external identifiers
  • scopus:85074553145
  • pmid:31619479
ISSN
1526-632X
DOI
10.1212/WNL.0000000000008459
language
English
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yes
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3f0ddea8-dd33-4fdd-a777-97a29bef9f47
date added to LUP
2019-11-18 13:26:33
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2020-01-13 02:31:46
@article{3f0ddea8-dd33-4fdd-a777-97a29bef9f47,
  abstract     = {Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.<br/><br/>The 3 common APOE alleles ε2, ε3, and ε4 can be separated by a combination of 2 single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Thus, associations with APOE alleles are not directly captured in a regular genome-wide association study (GWAS), where each SNP is investigated separately. We derived the 3 common APOE alleles and investigated the interplay between APOE, age at ischemic stroke onset, severity, sex, and outcome within a large international collaboration, the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network.},
  author       = {Lagging, Cecilia and Lorentzen, Erik and Stanne, Tara M. and Pedersen, Annie and Söderholm, Martin and Cole, John W. and Jood, Katarina and Lemmens, Robin and Phuah, Chia Ling and Rost, Natalia S. and Thijs, Vincent and Woo, Daniel and Maguire, Jane M. and Lindgren, Arne and Jern, Christina},
  issn         = {1526-632X},
  language     = {eng},
  number       = {19},
  pages        = {849--853},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome},
  url          = {http://dx.doi.org/10.1212/WNL.0000000000008459},
  doi          = {10.1212/WNL.0000000000008459},
  volume       = {93},
  year         = {2019},
}