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Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development : Evidence from experimental studies focused primarily on the rat

Jensen, Vivi F.H. LU ; Mølck, Anne Marie ; Lykkesfeldt, Jens and Bøgh, Ingrid B. (2018) In Reproductive Toxicology 77. p.1-24
Abstract

Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient... (More)

Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Fetal development, Gestation, Intra-uterine growth restriction, Malformations, Maternal hypoglycemia, Materno-foetal nutrient transfer, Skeletal development
in
Reproductive Toxicology
volume
77
pages
1 - 24
publisher
Elsevier
external identifiers
  • scopus:85041748155
  • pmid:29408374
ISSN
0890-6238
DOI
10.1016/j.reprotox.2018.01.007
language
English
LU publication?
no
id
3f520151-64dd-433b-8810-748e0d682bf6
date added to LUP
2019-01-04 14:33:53
date last changed
2024-04-15 20:20:27
@article{3f520151-64dd-433b-8810-748e0d682bf6,
  abstract     = {{<p>Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.</p>}},
  author       = {{Jensen, Vivi F.H. and Mølck, Anne Marie and Lykkesfeldt, Jens and Bøgh, Ingrid B.}},
  issn         = {{0890-6238}},
  keywords     = {{Fetal development; Gestation; Intra-uterine growth restriction; Malformations; Maternal hypoglycemia; Materno-foetal nutrient transfer; Skeletal development}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{1--24}},
  publisher    = {{Elsevier}},
  series       = {{Reproductive Toxicology}},
  title        = {{Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development : Evidence from experimental studies focused primarily on the rat}},
  url          = {{http://dx.doi.org/10.1016/j.reprotox.2018.01.007}},
  doi          = {{10.1016/j.reprotox.2018.01.007}},
  volume       = {{77}},
  year         = {{2018}},
}