VERANDERUNG DER INSULINSEKRETION ISOLIERTER LANGERHANS'SCHER INSELN DURCH BEHANDLUNG MIT NEURAMINIDASE
Hahn, H. J. LU ; Hellman, B. ; Lernmark, A. LU
and Taljedal, I. B.
(1974)
In Acta Biologica et Medica Germanica
32(4).
p.375-383
- Abstract
Treatment of pancreatic islets from ob/ob-mice with bacterial neuraminidase (0.8 to 40 mU/ml) resulted in a significant decrease of the sialic acid content and of the secretory response to glucose. The inhibitory effect on the glucose stimulated insulin release was reproduced with different batches of neuraminidase from Clostridium perfringens and Vibrio cholera. Treatment with neuraminidase affected neither the insulin content of the islets nor the potentiating effect of theophylline in the presence of 20 mM glucose. The results suggest that sialic acid plays a role in the mechanism of insulin release and that the inhibitory effect of sialic acid depletion is overcome by theophylline. (30 references.)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3f5a66f8-414b-4742-a157-238fa4e127f8
- author
- Hahn, H. J.
LU
; Hellman, B.
; Lernmark, A.
LU
and Taljedal, I. B.
- alternative title
- Changes in insulin secretion from pancreatic islets following treatment with neuraminidase
- publishing date
- 1974-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Acta Biologica et Medica Germanica
- volume
- 32
- issue
- 4
- pages
- 9 pages
- publisher
- Akademie Verlag GMBH
- external identifiers
-
- pmid:4605552
- scopus:0015998892
- ISSN
- 0001-5318
- language
- German
- LU publication?
- no
- id
- 3f5a66f8-414b-4742-a157-238fa4e127f8
- date added to LUP
- 2019-09-18 12:19:11
- date last changed
- 2024-03-13 08:28:19
@article{3f5a66f8-414b-4742-a157-238fa4e127f8,
abstract = {{<p>Treatment of pancreatic islets from ob/ob-mice with bacterial neuraminidase (0.8 to 40 mU/ml) resulted in a significant decrease of the sialic acid content and of the secretory response to glucose. The inhibitory effect on the glucose stimulated insulin release was reproduced with different batches of neuraminidase from Clostridium perfringens and Vibrio cholera. Treatment with neuraminidase affected neither the insulin content of the islets nor the potentiating effect of theophylline in the presence of 20 mM glucose. The results suggest that sialic acid plays a role in the mechanism of insulin release and that the inhibitory effect of sialic acid depletion is overcome by theophylline. (30 references.)</p>}},
author = {{Hahn, H. J. and Hellman, B. and Lernmark, A. and Taljedal, I. B.}},
issn = {{0001-5318}},
language = {{ger}},
month = {{01}},
number = {{4}},
pages = {{375--383}},
publisher = {{Akademie Verlag GMBH}},
series = {{Acta Biologica et Medica Germanica}},
title = {{VERANDERUNG DER INSULINSEKRETION ISOLIERTER LANGERHANS'SCHER INSELN DURCH BEHANDLUNG MIT NEURAMINIDASE}},
volume = {{32}},
year = {{1974}},
}