Cathelicidins - Nature's attempt at combinatorial chemistry
(2005) In Combinatorial Chemistry & High Throughput Screening 8(3). p.273-280- Abstract
- Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to... (More)
- Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to screen these peptides in experimentally relevant models that reflect the environments in which the peptides should be therapeutically active. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/246742
- author
- Sørensen, Ole E LU and Borregaard, N
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Combinatorial Chemistry & High Throughput Screening
- volume
- 8
- issue
- 3
- pages
- 273 - 280
- publisher
- Bentham Science Publishers
- external identifiers
-
- pmid:15892628
- wos:000228149700007
- scopus:16844384573
- ISSN
- 1386-2073
- DOI
- 10.2174/1386207053764602
- language
- English
- LU publication?
- yes
- id
- 3f82db0b-7fb5-4101-9226-b186f94f1fc7 (old id 246742)
- date added to LUP
- 2016-04-01 11:48:00
- date last changed
- 2022-01-26 18:24:35
@article{3f82db0b-7fb5-4101-9226-b186f94f1fc7,
abstract = {{Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to screen these peptides in experimentally relevant models that reflect the environments in which the peptides should be therapeutically active.}},
author = {{Sørensen, Ole E and Borregaard, N}},
issn = {{1386-2073}},
language = {{eng}},
number = {{3}},
pages = {{273--280}},
publisher = {{Bentham Science Publishers}},
series = {{Combinatorial Chemistry & High Throughput Screening}},
title = {{Cathelicidins - Nature's attempt at combinatorial chemistry}},
url = {{http://dx.doi.org/10.2174/1386207053764602}},
doi = {{10.2174/1386207053764602}},
volume = {{8}},
year = {{2005}},
}