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Hippocampal disconnection in early Alzheimer's disease : a 7 tesla MRI study

Wisse, Laura E M LU orcid ; Reijmer, Yael D ; ter Telgte, Annemieke ; Kuijf, Hugo J ; Leemans, Alexander ; Luijten, Peter R ; Koek, Huiberdina L ; Geerlings, Mirjam I and Biessels, Geert Jan (2015) In Journal of Alzheimer's disease : JAD 45(4). p.56-1247
Abstract

BACKGROUND: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts.

OBJECTIVE: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD.

METHODS: Twenty-five patients with amnestic mild cognitive impairment (aMCI) (n = 15) or early AD (n = 10) and 17 controls underwent 3 tesla diffusion MRI to obtain fractional anisotropy (FA) of the fornix and PHC and 7 tesla MRI to obtain ERC and hippocampal subfield volumes. Linear regression analyses were performed, adjusted for age, gender, and intracranial... (More)

BACKGROUND: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts.

OBJECTIVE: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD.

METHODS: Twenty-five patients with amnestic mild cognitive impairment (aMCI) (n = 15) or early AD (n = 10) and 17 controls underwent 3 tesla diffusion MRI to obtain fractional anisotropy (FA) of the fornix and PHC and 7 tesla MRI to obtain ERC and hippocampal subfield volumes. Linear regression analyses were performed, adjusted for age, gender, and intracranial volume.

RESULTS: Fornix FA was significantly lower and subiculum, cornu ammonis (CA) 1, and dentate gyrus &CA4 volume were significantly smaller in patients with MCI or AD as compared to controls. In patients with MCI or AD, fornix FA was positively associated with subiculum volume (β = 0.53, 95% CI 0.10; 0.96), but not with ERC/other subfield volumes. PHC FA was not associated with ERC/subfield volumes.

CONCLUSION: These findings indicate that in early AD subiculum atrophy is associated with lower FA of the fornix, which primarily consists of axons originating in the subiculum. This suggests that degeneration of subicular cell bodies and their axons are related processes in early AD.

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author
; ; ; ; ; ; ; and
author collaboration
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Alzheimer Disease/pathology, Anisotropy, Atrophy, Cognitive Dysfunction/pathology, Diffusion Magnetic Resonance Imaging/instrumentation, Female, Hippocampus/pathology, Humans, Image Processing, Computer-Assisted, Linear Models, Male, Organ Size
in
Journal of Alzheimer's disease : JAD
volume
45
issue
4
pages
10 pages
publisher
IOS Press
external identifiers
  • scopus:84928141352
  • pmid:25697703
ISSN
1387-2877
DOI
10.3233/JAD-142994
language
English
LU publication?
no
id
3fa9d184-b789-4250-a518-56ef5c5a715e
date added to LUP
2024-02-28 15:00:03
date last changed
2024-02-29 17:10:30
@article{3fa9d184-b789-4250-a518-56ef5c5a715e,
  abstract     = {{<p>BACKGROUND: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts.</p><p>OBJECTIVE: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD.</p><p>METHODS: Twenty-five patients with amnestic mild cognitive impairment (aMCI) (n = 15) or early AD (n = 10) and 17 controls underwent 3 tesla diffusion MRI to obtain fractional anisotropy (FA) of the fornix and PHC and 7 tesla MRI to obtain ERC and hippocampal subfield volumes. Linear regression analyses were performed, adjusted for age, gender, and intracranial volume.</p><p>RESULTS: Fornix FA was significantly lower and subiculum, cornu ammonis (CA) 1, and dentate gyrus &amp;CA4 volume were significantly smaller in patients with MCI or AD as compared to controls. In patients with MCI or AD, fornix FA was positively associated with subiculum volume (β = 0.53, 95% CI 0.10; 0.96), but not with ERC/other subfield volumes. PHC FA was not associated with ERC/subfield volumes.</p><p>CONCLUSION: These findings indicate that in early AD subiculum atrophy is associated with lower FA of the fornix, which primarily consists of axons originating in the subiculum. This suggests that degeneration of subicular cell bodies and their axons are related processes in early AD.</p>}},
  author       = {{Wisse, Laura E M and Reijmer, Yael D and ter Telgte, Annemieke and Kuijf, Hugo J and Leemans, Alexander and Luijten, Peter R and Koek, Huiberdina L and Geerlings, Mirjam I and Biessels, Geert Jan}},
  issn         = {{1387-2877}},
  keywords     = {{Aged; Alzheimer Disease/pathology; Anisotropy; Atrophy; Cognitive Dysfunction/pathology; Diffusion Magnetic Resonance Imaging/instrumentation; Female; Hippocampus/pathology; Humans; Image Processing, Computer-Assisted; Linear Models; Male; Organ Size}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{56--1247}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's disease : JAD}},
  title        = {{Hippocampal disconnection in early Alzheimer's disease : a 7 tesla MRI study}},
  url          = {{http://dx.doi.org/10.3233/JAD-142994}},
  doi          = {{10.3233/JAD-142994}},
  volume       = {{45}},
  year         = {{2015}},
}