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Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways

Grundemar, L LU ; Grundström, N ; Johansson, I G ; Andersson, R G and Håkanson, R LU (1990) In British Journal of Pharmacology 99(3). p.473-476
Abstract

1. In the present study we have examined whether neuropeptide Y (NPY) interferes with non-adrenergic, non-cholinergic nerve-mediated contractions and relaxations in the guinea-pig airways. In these experiments we have used ring preparations of bronchi and trachea, incubated in the presence of atropine, propranolol and indomethacin (each 1 microM). 2. The contractile response to electrical stimulation of non-adrenergic, non-cholinergic nerve fibres was suppressed by NPY and NPY 13-36 in a concentration-dependent manner, these agents having similar inhibitory potencies. NPY caused a more complete inhibition than the C terminal fragment. 3. NPY affected neither the basal tension nor the substance P-evoked contraction in the bronchi and... (More)

1. In the present study we have examined whether neuropeptide Y (NPY) interferes with non-adrenergic, non-cholinergic nerve-mediated contractions and relaxations in the guinea-pig airways. In these experiments we have used ring preparations of bronchi and trachea, incubated in the presence of atropine, propranolol and indomethacin (each 1 microM). 2. The contractile response to electrical stimulation of non-adrenergic, non-cholinergic nerve fibres was suppressed by NPY and NPY 13-36 in a concentration-dependent manner, these agents having similar inhibitory potencies. NPY caused a more complete inhibition than the C terminal fragment. 3. NPY affected neither the basal tension nor the substance P-evoked contraction in the bronchi and trachea and did not interfere with nerve-mediated, non-adrenergic relaxation in the trachea. 4. On the basis of these results, it is suggested that NPY may act on the terminals of sensory neurones in the airways to prevent antidromic, excitatory neurotransmission by inhibiting transmitter release.

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keywords
Animals, Atropine/pharmacology, Bronchi/drug effects, Capsaicin/pharmacology, Electric Stimulation, Guinea Pigs, In Vitro Techniques, Indomethacin/pharmacology, Male, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Neurons, Afferent/drug effects, Neuropeptide Y/pharmacology, Propranolol/pharmacology, Substance P/pharmacology, Synaptic Transmission/drug effects, Tetrodotoxin/pharmacology, Trachea/drug effects
in
British Journal of Pharmacology
volume
99
issue
3
pages
473 - 476
publisher
The British Pharmacological Society
external identifiers
  • scopus:0025174740
  • pmid:1691946
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1990.tb12952.x
language
English
LU publication?
yes
id
3fb19e2a-4a62-423d-a2d3-bfd9c8275427
date added to LUP
2019-09-03 14:13:43
date last changed
2020-01-13 02:19:29
@article{3fb19e2a-4a62-423d-a2d3-bfd9c8275427,
  abstract     = {<p>1. In the present study we have examined whether neuropeptide Y (NPY) interferes with non-adrenergic, non-cholinergic nerve-mediated contractions and relaxations in the guinea-pig airways. In these experiments we have used ring preparations of bronchi and trachea, incubated in the presence of atropine, propranolol and indomethacin (each 1 microM). 2. The contractile response to electrical stimulation of non-adrenergic, non-cholinergic nerve fibres was suppressed by NPY and NPY 13-36 in a concentration-dependent manner, these agents having similar inhibitory potencies. NPY caused a more complete inhibition than the C terminal fragment. 3. NPY affected neither the basal tension nor the substance P-evoked contraction in the bronchi and trachea and did not interfere with nerve-mediated, non-adrenergic relaxation in the trachea. 4. On the basis of these results, it is suggested that NPY may act on the terminals of sensory neurones in the airways to prevent antidromic, excitatory neurotransmission by inhibiting transmitter release.</p>},
  author       = {Grundemar, L and Grundström, N and Johansson, I G and Andersson, R G and Håkanson, R},
  issn         = {0007-1188},
  language     = {eng},
  number       = {3},
  pages        = {473--476},
  publisher    = {The British Pharmacological Society},
  series       = {British Journal of Pharmacology},
  title        = {Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways},
  url          = {http://dx.doi.org/10.1111/j.1476-5381.1990.tb12952.x},
  doi          = {10.1111/j.1476-5381.1990.tb12952.x},
  volume       = {99},
  year         = {1990},
}