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The application of CD antigen proteomics to pharmacogenomics

Woolfson, Adrian ; Ellmark, Peter LU ; Chrisp, Jeremy S. ; Scott, Mike A. and Christopherson, Richard I (2006) In Pharmacogenomics 7(5). p.759-771
Abstract
The advent of multiplexing technologies has raised the possibility that disease states can be defined using discrete genomic and proteomic patterns or signatures. However this emerging area has been limited by the 'content problem', arising from the uncertainty of which molecules to focus on. The human cluster of differentiation (CD) antigens are expressed on cells of the human immune system (leukocytes) and on other cell types. These heterogeneous molecules perform a host of roles essential to immune function and to the physiology of other lineages. The 339 defined CD antigens and their as yet, undefined counterparts constitute key components of the expressed human cell surface proteome. We propose that CD antigen expression patterns will... (More)
The advent of multiplexing technologies has raised the possibility that disease states can be defined using discrete genomic and proteomic patterns or signatures. However this emerging area has been limited by the 'content problem', arising from the uncertainty of which molecules to focus on. The human cluster of differentiation (CD) antigens are expressed on cells of the human immune system (leukocytes) and on other cell types. These heterogeneous molecules perform a host of roles essential to immune function and to the physiology of other lineages. The 339 defined CD antigens and their as yet, undefined counterparts constitute key components of the expressed human cell surface proteome. We propose that CD antigen expression patterns will form the basis of a rational, discrete and generalized diagnostic and prognostic system. Furthermore, disease-specific CD antigen proteomic signatures are likely to be more robust than corresponding genomic signatures and will also help to identify molecular targets for therapeutic intervention. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
human cluster of differentiation antigens, genomic signature, profiles, expression, cell surface antigens, CD antigen microarray, CD antigens, monoclonal antibody microarray, multiplexing technologies, proteomic, signature
in
Pharmacogenomics
volume
7
issue
5
pages
759 - 771
publisher
Future Medicine Ltd.
external identifiers
  • pmid:16886900
  • wos:000239072400013
  • scopus:33747135002
  • pmid:16886900
ISSN
1462-2416
DOI
10.2217/14622416.7.5.759
language
English
LU publication?
yes
id
fa52e110-3524-4568-9728-19fd15fcc62f (old id 402104)
date added to LUP
2016-04-01 12:15:11
date last changed
2021-02-17 03:56:12
@article{fa52e110-3524-4568-9728-19fd15fcc62f,
  abstract     = {The advent of multiplexing technologies has raised the possibility that disease states can be defined using discrete genomic and proteomic patterns or signatures. However this emerging area has been limited by the 'content problem', arising from the uncertainty of which molecules to focus on. The human cluster of differentiation (CD) antigens are expressed on cells of the human immune system (leukocytes) and on other cell types. These heterogeneous molecules perform a host of roles essential to immune function and to the physiology of other lineages. The 339 defined CD antigens and their as yet, undefined counterparts constitute key components of the expressed human cell surface proteome. We propose that CD antigen expression patterns will form the basis of a rational, discrete and generalized diagnostic and prognostic system. Furthermore, disease-specific CD antigen proteomic signatures are likely to be more robust than corresponding genomic signatures and will also help to identify molecular targets for therapeutic intervention.},
  author       = {Woolfson, Adrian and Ellmark, Peter and Chrisp, Jeremy S. and Scott, Mike A. and Christopherson, Richard I},
  issn         = {1462-2416},
  language     = {eng},
  number       = {5},
  pages        = {759--771},
  publisher    = {Future Medicine Ltd.},
  series       = {Pharmacogenomics},
  title        = {The application of CD antigen proteomics to pharmacogenomics},
  url          = {http://dx.doi.org/10.2217/14622416.7.5.759},
  doi          = {10.2217/14622416.7.5.759},
  volume       = {7},
  year         = {2006},
}