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Clinical correlation between adenosine deaminase activity and pre-eclampsia severity

Kafkasi, A. ; Karabulut, A. B. ; Atmaca, R. and Laurini, Ricardo (2006) In Journal of International Medical Research 34(3). p.247-255
Abstract
This study evaluated the relationship between the activity of the inflammatory indicator adenosine deaminase (ADA) in placental tissue and maternal and fetal (umbilical cord) plasma and the severity of pre-eclampsia. Maternal and umbilical vein whole blood and placental tissue samples were collected from women with normal pregnancies (n = 33) and patients with mild (n = 12) or severe (n = 17) pre-eclampsia. ADA activity was measured spectrophotometrically. Significantly increased ADA activity was detected in maternal and fetal plasma, and placental tissue in patients with mild and severe pre-eclampsia compared with normal pregnancies; there were no significant differences between the mild and severe cases. The presence of increased ADA... (More)
This study evaluated the relationship between the activity of the inflammatory indicator adenosine deaminase (ADA) in placental tissue and maternal and fetal (umbilical cord) plasma and the severity of pre-eclampsia. Maternal and umbilical vein whole blood and placental tissue samples were collected from women with normal pregnancies (n = 33) and patients with mild (n = 12) or severe (n = 17) pre-eclampsia. ADA activity was measured spectrophotometrically. Significantly increased ADA activity was detected in maternal and fetal plasma, and placental tissue in patients with mild and severe pre-eclampsia compared with normal pregnancies; there were no significant differences between the mild and severe cases. The presence of increased ADA activity in pre-eclampsia is consistent with activation of the inflammatory system in this condition. The increased ADA activity was related to the presence of the disease but not the severity of clinical symptoms. Neonatal outcome did not significantly correlate with observed ADA activity. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
placenia, pre-eclampsia, adenoside deaminase, fetus
in
Journal of International Medical Research
volume
34
issue
3
pages
247 - 255
publisher
Cambridge Medical Publications
external identifiers
  • wos:000238989100003
  • scopus:33745937662
ISSN
1473-2300
language
English
LU publication?
yes
id
a8b084ea-9b42-40db-8411-ee8136bfaec8 (old id 402158)
alternative location
http://www.jimronline.net/nav/issue.asp?IssueID=71#102
date added to LUP
2016-04-01 12:23:44
date last changed
2021-06-23 06:23:02
@article{a8b084ea-9b42-40db-8411-ee8136bfaec8,
  abstract     = {This study evaluated the relationship between the activity of the inflammatory indicator adenosine deaminase (ADA) in placental tissue and maternal and fetal (umbilical cord) plasma and the severity of pre-eclampsia. Maternal and umbilical vein whole blood and placental tissue samples were collected from women with normal pregnancies (n = 33) and patients with mild (n = 12) or severe (n = 17) pre-eclampsia. ADA activity was measured spectrophotometrically. Significantly increased ADA activity was detected in maternal and fetal plasma, and placental tissue in patients with mild and severe pre-eclampsia compared with normal pregnancies; there were no significant differences between the mild and severe cases. The presence of increased ADA activity in pre-eclampsia is consistent with activation of the inflammatory system in this condition. The increased ADA activity was related to the presence of the disease but not the severity of clinical symptoms. Neonatal outcome did not significantly correlate with observed ADA activity.},
  author       = {Kafkasi, A. and Karabulut, A. B. and Atmaca, R. and Laurini, Ricardo},
  issn         = {1473-2300},
  language     = {eng},
  number       = {3},
  pages        = {247--255},
  publisher    = {Cambridge Medical Publications},
  series       = {Journal of International Medical Research},
  title        = {Clinical correlation between adenosine deaminase activity and pre-eclampsia severity},
  url          = {http://www.jimronline.net/nav/issue.asp?IssueID=71#102},
  volume       = {34},
  year         = {2006},
}