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PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta.

Ohlsson, R.; Falck, P.; Hellström, M.; Lindahl, P.; Ehrencrona, Hans LU ; Franklin, G.; Ahrlund-Richter, L.; Pollard, J.; Soriano, P. and Betsholtz, C. (1999) In Developmental Biology 212(1). p.124-136
Abstract
PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated embryonic blood vessels and reduced numbers of both pericytes and trophoblasts. These changes are seen from embryonic day (E) 13.5, which coincides with the upregulation of PDGFB mRNA levels in normal placentas. By E17, modifications in shape, size, and number of the fetal blood vessels in the mutant placentas cause an abnormal ratio of the surface areas between the fetal and the maternal blood vessels in the labyrinthine... (More)
PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated embryonic blood vessels and reduced numbers of both pericytes and trophoblasts. These changes are seen from embryonic day (E) 13.5, which coincides with the upregulation of PDGFB mRNA levels in normal placentas. By E17, modifications in shape, size, and number of the fetal blood vessels in the mutant placentas cause an abnormal ratio of the surface areas between the fetal and the maternal blood vessels in the labyrinthine layer. Our data suggest that PDGFB acts locally to contribute to the development of the labyrinthine layer of the fetal placenta and the formation of a proper nutrient-waste exchange system during fetal development. We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Proto-Oncogene Proteins, Pregnancy, Platelet-Derived Growth Factor, Placenta, Pericytes, Biological, Models, Knockout, Mice, Maternal-Fetal Exchange, Kidney, Female, Animals, Capillaries, Proto-Oncogene Proteins c-sis, Receptors, Time Factors, Trophoblasts
in
Developmental Biology
volume
212
issue
1
pages
124 - 136
publisher
Elsevier
external identifiers
  • scopus:0033179034
ISSN
1095-564X
language
English
LU publication?
no
id
b00059eb-897d-495a-af87-311ddd707d13 (old id 4021938)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/10419690
http://dx.doi.org/10.1006/dbio.1999.9306
date added to LUP
2013-10-21 10:52:32
date last changed
2017-01-22 04:16:34
@article{b00059eb-897d-495a-af87-311ddd707d13,
  abstract     = {PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated embryonic blood vessels and reduced numbers of both pericytes and trophoblasts. These changes are seen from embryonic day (E) 13.5, which coincides with the upregulation of PDGFB mRNA levels in normal placentas. By E17, modifications in shape, size, and number of the fetal blood vessels in the mutant placentas cause an abnormal ratio of the surface areas between the fetal and the maternal blood vessels in the labyrinthine layer. Our data suggest that PDGFB acts locally to contribute to the development of the labyrinthine layer of the fetal placenta and the formation of a proper nutrient-waste exchange system during fetal development. We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney.},
  author       = {Ohlsson, R. and Falck, P. and Hellström, M. and Lindahl, P. and Ehrencrona, Hans and Franklin, G. and Ahrlund-Richter, L. and Pollard, J. and Soriano, P. and Betsholtz, C.},
  issn         = {1095-564X},
  keyword      = {Proto-Oncogene Proteins,Pregnancy,Platelet-Derived Growth Factor,Placenta,Pericytes,Biological,Models,Knockout,Mice,Maternal-Fetal Exchange,Kidney,Female,Animals,Capillaries,Proto-Oncogene Proteins c-sis,Receptors,Time Factors,Trophoblasts},
  language     = {eng},
  number       = {1},
  pages        = {124--136},
  publisher    = {Elsevier},
  series       = {Developmental Biology},
  title        = {PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta.},
  volume       = {212},
  year         = {1999},
}