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MRI and non-cartilaginous structures in knee osteoarthritis

Conaghan, P. G. ; Felson, D. ; Gold, G. ; Lohmander, Stefan LU ; Totterman, S. and Altman, R. (2006) In Osteoarthritis and Cartilage 14(Suppl. 1). p.87-94
Abstract
Magnetic resonance imaging (MRI) provides a sensitive tool for examining all the structures involved in the osteoarthritis (OA) process. While much of the MRI literature previously focussed on cartilage, there is increasing research on whole-organ evaluation and including features such as synovitis, bone marrow edema, and meniscal and ligamentous pathology. The aim of this session at the Outcome Measures in Rheumatology Clinical Trials (OMERACT)-Osteoarthritis Research Society International (OARSI) Workshop for Consensus in Osteoarthritis Imaging was to describe the current MRI methods for identifying and quantifying non-cartilaginous structures and review their associations with both CIA symptoms and structural progression. Although there... (More)
Magnetic resonance imaging (MRI) provides a sensitive tool for examining all the structures involved in the osteoarthritis (OA) process. While much of the MRI literature previously focussed on cartilage, there is increasing research on whole-organ evaluation and including features such as synovitis, bone marrow edema, and meniscal and ligamentous pathology. The aim of this session at the Outcome Measures in Rheumatology Clinical Trials (OMERACT)-Osteoarthritis Research Society International (OARSI) Workshop for Consensus in Osteoarthritis Imaging was to describe the current MRI methods for identifying and quantifying non-cartilaginous structures and review their associations with both CIA symptoms and structural progression. Although there is much experience in measuring synovitis (derived from the rheumatoid arthritis literature), only one study has reported an association of MRI-detected synovitis and effusions with OA pain. Bone marrow edema lesions, which may represent areas of trabecular remodelling, have been associated with pain and compartment-specific structural deterioration. MRI studies have confirmed the frequency and importance of meniscal damage in progressive cartilage loss, but not related such damage to symptoms. Osteophytes have been associated with cartilage loss and malalignment to the side of the osteophyte. Ligament damage, including anterior cruciate ligament tears, has been found more commonly than expected in painful CA knees. Improvements in quantitative and semi-quantitative assessments of non-cartilage features will greatly assist understanding of the CA process and its response to therapy. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
subchondral bone, synovium, MRI, osteoarthritis, knee, ligaments, menisci
in
Osteoarthritis and Cartilage
volume
14
issue
Suppl. 1
pages
87 - 94
publisher
Elsevier
external identifiers
  • wos:000238959700012
  • scopus:33745134085
ISSN
1063-4584
DOI
10.1016/j.joca.2006.02.028
language
English
LU publication?
yes
id
0e2912b8-e922-4c83-8439-6ab24ce80d0e (old id 403917)
date added to LUP
2016-04-01 11:44:22
date last changed
2020-11-16 02:47:44
@article{0e2912b8-e922-4c83-8439-6ab24ce80d0e,
  abstract     = {Magnetic resonance imaging (MRI) provides a sensitive tool for examining all the structures involved in the osteoarthritis (OA) process. While much of the MRI literature previously focussed on cartilage, there is increasing research on whole-organ evaluation and including features such as synovitis, bone marrow edema, and meniscal and ligamentous pathology. The aim of this session at the Outcome Measures in Rheumatology Clinical Trials (OMERACT)-Osteoarthritis Research Society International (OARSI) Workshop for Consensus in Osteoarthritis Imaging was to describe the current MRI methods for identifying and quantifying non-cartilaginous structures and review their associations with both CIA symptoms and structural progression. Although there is much experience in measuring synovitis (derived from the rheumatoid arthritis literature), only one study has reported an association of MRI-detected synovitis and effusions with OA pain. Bone marrow edema lesions, which may represent areas of trabecular remodelling, have been associated with pain and compartment-specific structural deterioration. MRI studies have confirmed the frequency and importance of meniscal damage in progressive cartilage loss, but not related such damage to symptoms. Osteophytes have been associated with cartilage loss and malalignment to the side of the osteophyte. Ligament damage, including anterior cruciate ligament tears, has been found more commonly than expected in painful CA knees. Improvements in quantitative and semi-quantitative assessments of non-cartilage features will greatly assist understanding of the CA process and its response to therapy. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
  author       = {Conaghan, P. G. and Felson, D. and Gold, G. and Lohmander, Stefan and Totterman, S. and Altman, R.},
  issn         = {1063-4584},
  language     = {eng},
  number       = {Suppl. 1},
  pages        = {87--94},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {MRI and non-cartilaginous structures in knee osteoarthritis},
  url          = {http://dx.doi.org/10.1016/j.joca.2006.02.028},
  doi          = {10.1016/j.joca.2006.02.028},
  volume       = {14},
  year         = {2006},
}