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Short-term administration of ACTH improves plasma lipid profile and renal function in kidney transplant patients

He, X ; Xue, P ; Xu, X ; Luo, G ; Zhou, G ; Nilsson-Ehle, Peter LU and Xu, Ning LU (2006) In Transplantation Proceedings 38(5). p.1371-1374
Abstract
The present study investigated effects of short-term administration of adrenocorticotrophic hormone (ACTH) on blood lipid profile and renal function in kidney transplant patients. Six patients who had kidney transplantations 2 to 10 years earlier received ACTH intramuscularly (1 mg/d) for 4 days. We analyzed serum levels of lipids, lipoproteins, apolipoproteins, blood creatinine, and other parameters. Short-term ACTH treatment significantly decreased serum apolipoprotein B and apolipoprotein AI, whereas it significantly increased plasma high-density lipoproteins (HDL). Interestingly, creatinine level moderately decreased and creatinine clearances moderately increased among five of six patients. Hepatic function and serum concentration of... (More)
The present study investigated effects of short-term administration of adrenocorticotrophic hormone (ACTH) on blood lipid profile and renal function in kidney transplant patients. Six patients who had kidney transplantations 2 to 10 years earlier received ACTH intramuscularly (1 mg/d) for 4 days. We analyzed serum levels of lipids, lipoproteins, apolipoproteins, blood creatinine, and other parameters. Short-term ACTH treatment significantly decreased serum apolipoprotein B and apolipoprotein AI, whereas it significantly increased plasma high-density lipoproteins (HDL). Interestingly, creatinine level moderately decreased and creatinine clearances moderately increased among five of six patients. Hepatic function and serum concentration of cyclosporine did not change. There were no serious side effects during ACTH treatment. It was concluded that ACTH treatment had beneficial effects on serum lipoprotein profile, potentially improving renal function in kidney transplant patients. Further observations are needed to confirm these effects. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Transplantation Proceedings
volume
38
issue
5
pages
1371 - 1374
publisher
Elsevier
external identifiers
  • pmid:16797307
  • wos:000238700500042
  • scopus:33745203919
ISSN
0041-1345
DOI
10.1016/j.transproceed.2006.02.090
language
English
LU publication?
yes
id
3691a668-387a-4deb-87be-42b15714d64a (old id 404317)
date added to LUP
2016-04-01 11:41:43
date last changed
2020-01-12 08:25:20
@article{3691a668-387a-4deb-87be-42b15714d64a,
  abstract     = {The present study investigated effects of short-term administration of adrenocorticotrophic hormone (ACTH) on blood lipid profile and renal function in kidney transplant patients. Six patients who had kidney transplantations 2 to 10 years earlier received ACTH intramuscularly (1 mg/d) for 4 days. We analyzed serum levels of lipids, lipoproteins, apolipoproteins, blood creatinine, and other parameters. Short-term ACTH treatment significantly decreased serum apolipoprotein B and apolipoprotein AI, whereas it significantly increased plasma high-density lipoproteins (HDL). Interestingly, creatinine level moderately decreased and creatinine clearances moderately increased among five of six patients. Hepatic function and serum concentration of cyclosporine did not change. There were no serious side effects during ACTH treatment. It was concluded that ACTH treatment had beneficial effects on serum lipoprotein profile, potentially improving renal function in kidney transplant patients. Further observations are needed to confirm these effects.},
  author       = {He, X and Xue, P and Xu, X and Luo, G and Zhou, G and Nilsson-Ehle, Peter and Xu, Ning},
  issn         = {0041-1345},
  language     = {eng},
  number       = {5},
  pages        = {1371--1374},
  publisher    = {Elsevier},
  series       = {Transplantation Proceedings},
  title        = {Short-term administration of ACTH improves plasma lipid profile and renal function in kidney transplant patients},
  url          = {http://dx.doi.org/10.1016/j.transproceed.2006.02.090},
  doi          = {10.1016/j.transproceed.2006.02.090},
  volume       = {38},
  year         = {2006},
}