Short-term administration of ACTH improves plasma lipid profile and renal function in kidney transplant patients
(2006) In Transplantation Proceedings 38(5). p.1371-1374- Abstract
- The present study investigated effects of short-term administration of adrenocorticotrophic hormone (ACTH) on blood lipid profile and renal function in kidney transplant patients. Six patients who had kidney transplantations 2 to 10 years earlier received ACTH intramuscularly (1 mg/d) for 4 days. We analyzed serum levels of lipids, lipoproteins, apolipoproteins, blood creatinine, and other parameters. Short-term ACTH treatment significantly decreased serum apolipoprotein B and apolipoprotein AI, whereas it significantly increased plasma high-density lipoproteins (HDL). Interestingly, creatinine level moderately decreased and creatinine clearances moderately increased among five of six patients. Hepatic function and serum concentration of... (More)
- The present study investigated effects of short-term administration of adrenocorticotrophic hormone (ACTH) on blood lipid profile and renal function in kidney transplant patients. Six patients who had kidney transplantations 2 to 10 years earlier received ACTH intramuscularly (1 mg/d) for 4 days. We analyzed serum levels of lipids, lipoproteins, apolipoproteins, blood creatinine, and other parameters. Short-term ACTH treatment significantly decreased serum apolipoprotein B and apolipoprotein AI, whereas it significantly increased plasma high-density lipoproteins (HDL). Interestingly, creatinine level moderately decreased and creatinine clearances moderately increased among five of six patients. Hepatic function and serum concentration of cyclosporine did not change. There were no serious side effects during ACTH treatment. It was concluded that ACTH treatment had beneficial effects on serum lipoprotein profile, potentially improving renal function in kidney transplant patients. Further observations are needed to confirm these effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/404317
- author
- He, X ; Xue, P ; Xu, X ; Luo, G ; Zhou, G ; Nilsson-Ehle, Peter LU and Xu, Ning LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Transplantation Proceedings
- volume
- 38
- issue
- 5
- pages
- 1371 - 1374
- publisher
- Elsevier
- external identifiers
-
- pmid:16797307
- wos:000238700500042
- scopus:33745203919
- ISSN
- 0041-1345
- DOI
- 10.1016/j.transproceed.2006.02.090
- language
- English
- LU publication?
- yes
- id
- 3691a668-387a-4deb-87be-42b15714d64a (old id 404317)
- date added to LUP
- 2016-04-01 11:41:43
- date last changed
- 2022-03-05 05:08:26
@article{3691a668-387a-4deb-87be-42b15714d64a, abstract = {{The present study investigated effects of short-term administration of adrenocorticotrophic hormone (ACTH) on blood lipid profile and renal function in kidney transplant patients. Six patients who had kidney transplantations 2 to 10 years earlier received ACTH intramuscularly (1 mg/d) for 4 days. We analyzed serum levels of lipids, lipoproteins, apolipoproteins, blood creatinine, and other parameters. Short-term ACTH treatment significantly decreased serum apolipoprotein B and apolipoprotein AI, whereas it significantly increased plasma high-density lipoproteins (HDL). Interestingly, creatinine level moderately decreased and creatinine clearances moderately increased among five of six patients. Hepatic function and serum concentration of cyclosporine did not change. There were no serious side effects during ACTH treatment. It was concluded that ACTH treatment had beneficial effects on serum lipoprotein profile, potentially improving renal function in kidney transplant patients. Further observations are needed to confirm these effects.}}, author = {{He, X and Xue, P and Xu, X and Luo, G and Zhou, G and Nilsson-Ehle, Peter and Xu, Ning}}, issn = {{0041-1345}}, language = {{eng}}, number = {{5}}, pages = {{1371--1374}}, publisher = {{Elsevier}}, series = {{Transplantation Proceedings}}, title = {{Short-term administration of ACTH improves plasma lipid profile and renal function in kidney transplant patients}}, url = {{http://dx.doi.org/10.1016/j.transproceed.2006.02.090}}, doi = {{10.1016/j.transproceed.2006.02.090}}, volume = {{38}}, year = {{2006}}, }