Neuronal signal substances as biomarkers of migraine
(2006) In Headache 46(7). p.1088-1094- Abstract
- Of the sensory nervous system associated signal substances it is only calcitonin generelated peptide (CGRP) that is reliably associated with the degree of pain in the acute attacks of primary headaches. The treatment with triptans alleviates both the pain and the associated CGRP release, putatively via a presynaptic effect on the sensory nerves. The studies of opoids and other sensory neuropeptides are inconsistent and require further analysis. Initial positive data on endothelin and its receptors have turned out negative. Nitric oxide mechanisms are still debated both in terms of initiation of attacks and for the treatment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/404547
- author
- Edvinsson, Lars LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- neuronal signal substances, primary headaches
- in
- Headache
- volume
- 46
- issue
- 7
- pages
- 1088 - 1094
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000238748700008
- scopus:33745611399
- pmid:16866713
- ISSN
- 1526-4610
- DOI
- 10.1111/j.1526-4610.2006.00502.x
- language
- English
- LU publication?
- yes
- id
- b4826cb9-2924-4513-886d-b15399edb694 (old id 404547)
- date added to LUP
- 2016-04-01 15:50:33
- date last changed
- 2024-01-10 20:44:00
@article{b4826cb9-2924-4513-886d-b15399edb694, abstract = {{Of the sensory nervous system associated signal substances it is only calcitonin generelated peptide (CGRP) that is reliably associated with the degree of pain in the acute attacks of primary headaches. The treatment with triptans alleviates both the pain and the associated CGRP release, putatively via a presynaptic effect on the sensory nerves. The studies of opoids and other sensory neuropeptides are inconsistent and require further analysis. Initial positive data on endothelin and its receptors have turned out negative. Nitric oxide mechanisms are still debated both in terms of initiation of attacks and for the treatment.}}, author = {{Edvinsson, Lars}}, issn = {{1526-4610}}, keywords = {{neuronal signal substances; primary headaches}}, language = {{eng}}, number = {{7}}, pages = {{1088--1094}}, publisher = {{Wiley-Blackwell}}, series = {{Headache}}, title = {{Neuronal signal substances as biomarkers of migraine}}, url = {{http://dx.doi.org/10.1111/j.1526-4610.2006.00502.x}}, doi = {{10.1111/j.1526-4610.2006.00502.x}}, volume = {{46}}, year = {{2006}}, }