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Neuronal signal substances as biomarkers of migraine

Edvinsson, Lars LU (2006) In Headache 46(7). p.1088-1094
Abstract
Of the sensory nervous system associated signal substances it is only calcitonin generelated peptide (CGRP) that is reliably associated with the degree of pain in the acute attacks of primary headaches. The treatment with triptans alleviates both the pain and the associated CGRP release, putatively via a presynaptic effect on the sensory nerves. The studies of opoids and other sensory neuropeptides are inconsistent and require further analysis. Initial positive data on endothelin and its receptors have turned out negative. Nitric oxide mechanisms are still debated both in terms of initiation of attacks and for the treatment.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neuronal signal substances, primary headaches
in
Headache
volume
46
issue
7
pages
1088 - 1094
publisher
Wiley-Blackwell
external identifiers
  • wos:000238748700008
  • scopus:33745611399
  • pmid:16866713
ISSN
1526-4610
DOI
10.1111/j.1526-4610.2006.00502.x
language
English
LU publication?
yes
id
b4826cb9-2924-4513-886d-b15399edb694 (old id 404547)
date added to LUP
2016-04-01 15:50:33
date last changed
2020-01-12 18:47:22
@article{b4826cb9-2924-4513-886d-b15399edb694,
  abstract     = {Of the sensory nervous system associated signal substances it is only calcitonin generelated peptide (CGRP) that is reliably associated with the degree of pain in the acute attacks of primary headaches. The treatment with triptans alleviates both the pain and the associated CGRP release, putatively via a presynaptic effect on the sensory nerves. The studies of opoids and other sensory neuropeptides are inconsistent and require further analysis. Initial positive data on endothelin and its receptors have turned out negative. Nitric oxide mechanisms are still debated both in terms of initiation of attacks and for the treatment.},
  author       = {Edvinsson, Lars},
  issn         = {1526-4610},
  language     = {eng},
  number       = {7},
  pages        = {1088--1094},
  publisher    = {Wiley-Blackwell},
  series       = {Headache},
  title        = {Neuronal signal substances as biomarkers of migraine},
  url          = {http://dx.doi.org/10.1111/j.1526-4610.2006.00502.x},
  doi          = {10.1111/j.1526-4610.2006.00502.x},
  volume       = {46},
  year         = {2006},
}