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Low density and high affinity of platelet [H-3]paroxetine binding in women with bulimia nervosa

Ekman, A ; Sundblad-Elverfors, C ; Landen, M ; Eriksson, Tomas LU and Eriksson, E (2006) In Psychiatry Research 142(2-3). p.219-223
Abstract
Impaired serotonin transmission has been suggested to be implicated in the pathophysiology of bulimia nervosa. As an indirect measure of brain serotonergic activity, the binding of tritiated ligands to platelet serotonin transporters has been studied in bulimia nervosa as well as in other putatively serotonin-related psychiatric disorders. In this study, the density and affinity of platelet serotonin transporters were assessed in 20 women meeting the DSM-IV criteria for bulimia nervosa and in 14 controls without previous or ongoing eating disorder using [H-3]paroxetine as a ligand. In comparison to controls, women with bulimia nervosa had a significantly reduced number of platelet binding sites (B-max=721 +/- 313 vs. 1145 +/- 293 fmol/mg... (More)
Impaired serotonin transmission has been suggested to be implicated in the pathophysiology of bulimia nervosa. As an indirect measure of brain serotonergic activity, the binding of tritiated ligands to platelet serotonin transporters has been studied in bulimia nervosa as well as in other putatively serotonin-related psychiatric disorders. In this study, the density and affinity of platelet serotonin transporters were assessed in 20 women meeting the DSM-IV criteria for bulimia nervosa and in 14 controls without previous or ongoing eating disorder using [H-3]paroxetine as a ligand. In comparison to controls, women with bulimia nervosa had a significantly reduced number of platelet binding sites (B-max=721 +/- 313 vs. 1145 +/- 293 fmol/mg protein) and an increase in the affinity for the ligand demonstrated by a lower dissociaton constant (K-d=33 +/- 10 vs. 44 +/- 10 pM). A significant correlation between B-max and K-d values was found in patients but not in controls. Our results support the notion that bulimia nervosa is associated with a reduction in platelet serotonin transporter density. In addition, our study is the first to report that this reduced transporter density in women with bulimia nervosa is accompanied by an increase in the affinity of the transporter for the ligand. (c) 2006 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
women, [H-3]paroxetine binding, bulimia nervosa, platelets, serotonin transporter, K-d, B-max
in
Psychiatry Research
volume
142
issue
2-3
pages
219 - 223
publisher
Elsevier
external identifiers
  • wos:000238625900011
  • scopus:33646851374
ISSN
1872-7123
DOI
10.1016/j.psychres.2006.02.012
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: The Biological Psychiatry Research Group (013243110), Division of Health Economics and Forensic Medicine (Closed 2012) (013040050)
id
c83f7828-298c-47a2-b7a9-bdff53f43117 (old id 404769)
date added to LUP
2016-04-01 12:28:19
date last changed
2021-02-17 04:58:18
@article{c83f7828-298c-47a2-b7a9-bdff53f43117,
  abstract     = {Impaired serotonin transmission has been suggested to be implicated in the pathophysiology of bulimia nervosa. As an indirect measure of brain serotonergic activity, the binding of tritiated ligands to platelet serotonin transporters has been studied in bulimia nervosa as well as in other putatively serotonin-related psychiatric disorders. In this study, the density and affinity of platelet serotonin transporters were assessed in 20 women meeting the DSM-IV criteria for bulimia nervosa and in 14 controls without previous or ongoing eating disorder using [H-3]paroxetine as a ligand. In comparison to controls, women with bulimia nervosa had a significantly reduced number of platelet binding sites (B-max=721 +/- 313 vs. 1145 +/- 293 fmol/mg protein) and an increase in the affinity for the ligand demonstrated by a lower dissociaton constant (K-d=33 +/- 10 vs. 44 +/- 10 pM). A significant correlation between B-max and K-d values was found in patients but not in controls. Our results support the notion that bulimia nervosa is associated with a reduction in platelet serotonin transporter density. In addition, our study is the first to report that this reduced transporter density in women with bulimia nervosa is accompanied by an increase in the affinity of the transporter for the ligand. (c) 2006 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Ekman, A and Sundblad-Elverfors, C and Landen, M and Eriksson, Tomas and Eriksson, E},
  issn         = {1872-7123},
  language     = {eng},
  number       = {2-3},
  pages        = {219--223},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Low density and high affinity of platelet [H-3]paroxetine binding in women with bulimia nervosa},
  url          = {http://dx.doi.org/10.1016/j.psychres.2006.02.012},
  doi          = {10.1016/j.psychres.2006.02.012},
  volume       = {142},
  year         = {2006},
}