The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications.
(2013) In Expert Review of Medical Devices 10(5). p.675-684- Abstract
- Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics... (More)
- Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4065581
- author
- Nilsson, Malin K LU ; Zheng, Ming H and Tägil, Magnus LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Expert Review of Medical Devices
- volume
- 10
- issue
- 5
- pages
- 675 - 684
- publisher
- Expert Reviews
- external identifiers
-
- wos:000324647000017
- pmid:24053255
- scopus:84886923527
- pmid:24053255
- ISSN
- 1745-2422
- DOI
- 10.1586/17434440.2013.827529
- language
- English
- LU publication?
- yes
- id
- ed8dfe12-2c0a-4133-bc9d-36beec05e02c (old id 4065581)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24053255?dopt=Abstract
- date added to LUP
- 2016-04-01 10:57:49
- date last changed
- 2022-04-20 07:43:36
@article{ed8dfe12-2c0a-4133-bc9d-36beec05e02c,
abstract = {{Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future.}},
author = {{Nilsson, Malin K and Zheng, Ming H and Tägil, Magnus}},
issn = {{1745-2422}},
language = {{eng}},
number = {{5}},
pages = {{675--684}},
publisher = {{Expert Reviews}},
series = {{Expert Review of Medical Devices}},
title = {{The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications.}},
url = {{http://dx.doi.org/10.1586/17434440.2013.827529}},
doi = {{10.1586/17434440.2013.827529}},
volume = {{10}},
year = {{2013}},
}