Advanced

Midkine in Host Defense.

Gela, Anele LU ; Jovic, Sandra LU ; Nordin, Sara LU and Egesten, Arne LU (2014) In British Journal of Pharmacology 171(4). p.859-869
Abstract
Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e. recruitment and activation of neutrophils and macrophages). Indeed, recent research has demonstrated potent bactericidal and fungicidal activities of midkine. This protein is constitutively expressed at relevant concentrations at barriers of the body, such as in the skin and in the large airways, where the body first encounters potential pathogens. The antibacterial properties of midkine orthologues are preserved during evolution, as exemplified by miple2 of Drosophila. In addition to retinoic acid, gene expression can be promoted by additional... (More)
Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e. recruitment and activation of neutrophils and macrophages). Indeed, recent research has demonstrated potent bactericidal and fungicidal activities of midkine. This protein is constitutively expressed at relevant concentrations at barriers of the body, such as in the skin and in the large airways, where the body first encounters potential pathogens. The antibacterial properties of midkine orthologues are preserved during evolution, as exemplified by miple2 of Drosophila. In addition to retinoic acid, gene expression can be promoted by additional factors present at sites of infection, reactive oxygen species, activation of the transcription factor NFκ-B, and hypoxia. In the light of the emerging resistance of pathogenic bacteria to conventional antibiotics, midkine is an interesting molecule that could serve as a template in developing novel pharmaceutical strategies against bacterial and fungal infections, either alone or in combination with conventional antibiotics. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Pharmacology
volume
171
issue
4
pages
859 - 869
publisher
The British Pharmacological Society
external identifiers
  • wos:000330087000006
  • pmid:24024937
  • scopus:84893092456
ISSN
1476-5381
DOI
10.1111/bph.12402
language
English
LU publication?
yes
id
2f1db4f4-5b66-4881-8058-62dc61b926a0 (old id 4065986)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24024937?dopt=Abstract
date added to LUP
2013-10-01 21:14:32
date last changed
2017-07-30 03:20:18
@article{2f1db4f4-5b66-4881-8058-62dc61b926a0,
  abstract     = {Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e. recruitment and activation of neutrophils and macrophages). Indeed, recent research has demonstrated potent bactericidal and fungicidal activities of midkine. This protein is constitutively expressed at relevant concentrations at barriers of the body, such as in the skin and in the large airways, where the body first encounters potential pathogens. The antibacterial properties of midkine orthologues are preserved during evolution, as exemplified by miple2 of Drosophila. In addition to retinoic acid, gene expression can be promoted by additional factors present at sites of infection, reactive oxygen species, activation of the transcription factor NFκ-B, and hypoxia. In the light of the emerging resistance of pathogenic bacteria to conventional antibiotics, midkine is an interesting molecule that could serve as a template in developing novel pharmaceutical strategies against bacterial and fungal infections, either alone or in combination with conventional antibiotics.},
  author       = {Gela, Anele and Jovic, Sandra and Nordin, Sara and Egesten, Arne},
  issn         = {1476-5381},
  language     = {eng},
  number       = {4},
  pages        = {859--869},
  publisher    = {The British Pharmacological Society},
  series       = {British Journal of Pharmacology},
  title        = {Midkine in Host Defense.},
  url          = {http://dx.doi.org/10.1111/bph.12402},
  volume       = {171},
  year         = {2014},
}