Midkine in Host Defense.
(2014) In British Journal of Pharmacology 171(4). p.859-869- Abstract
- Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e. recruitment and activation of neutrophils and macrophages). Indeed, recent research has demonstrated potent bactericidal and fungicidal activities of midkine. This protein is constitutively expressed at relevant concentrations at barriers of the body, such as in the skin and in the large airways, where the body first encounters potential pathogens. The antibacterial properties of midkine orthologues are preserved during evolution, as exemplified by miple2 of Drosophila. In addition to retinoic acid, gene expression can be promoted by additional... (More)
- Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e. recruitment and activation of neutrophils and macrophages). Indeed, recent research has demonstrated potent bactericidal and fungicidal activities of midkine. This protein is constitutively expressed at relevant concentrations at barriers of the body, such as in the skin and in the large airways, where the body first encounters potential pathogens. The antibacterial properties of midkine orthologues are preserved during evolution, as exemplified by miple2 of Drosophila. In addition to retinoic acid, gene expression can be promoted by additional factors present at sites of infection, reactive oxygen species, activation of the transcription factor NFκ-B, and hypoxia. In the light of the emerging resistance of pathogenic bacteria to conventional antibiotics, midkine is an interesting molecule that could serve as a template in developing novel pharmaceutical strategies against bacterial and fungal infections, either alone or in combination with conventional antibiotics. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4065986
- author
- Gela, Anele LU ; Jovic, Sandra LU ; Nordin, Sara LU and Egesten, Arne LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Pharmacology
- volume
- 171
- issue
- 4
- pages
- 859 - 869
- publisher
- Wiley
- external identifiers
-
- wos:000330087000006
- pmid:24024937
- scopus:84893092456
- pmid:24024937
- ISSN
- 1476-5381
- DOI
- 10.1111/bph.12402
- language
- English
- LU publication?
- yes
- id
- 2f1db4f4-5b66-4881-8058-62dc61b926a0 (old id 4065986)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24024937?dopt=Abstract
- date added to LUP
- 2016-04-01 10:44:05
- date last changed
- 2022-02-02 20:32:58
@article{2f1db4f4-5b66-4881-8058-62dc61b926a0,
abstract = {{Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e. recruitment and activation of neutrophils and macrophages). Indeed, recent research has demonstrated potent bactericidal and fungicidal activities of midkine. This protein is constitutively expressed at relevant concentrations at barriers of the body, such as in the skin and in the large airways, where the body first encounters potential pathogens. The antibacterial properties of midkine orthologues are preserved during evolution, as exemplified by miple2 of Drosophila. In addition to retinoic acid, gene expression can be promoted by additional factors present at sites of infection, reactive oxygen species, activation of the transcription factor NFκ-B, and hypoxia. In the light of the emerging resistance of pathogenic bacteria to conventional antibiotics, midkine is an interesting molecule that could serve as a template in developing novel pharmaceutical strategies against bacterial and fungal infections, either alone or in combination with conventional antibiotics.}},
author = {{Gela, Anele and Jovic, Sandra and Nordin, Sara and Egesten, Arne}},
issn = {{1476-5381}},
language = {{eng}},
number = {{4}},
pages = {{859--869}},
publisher = {{Wiley}},
series = {{British Journal of Pharmacology}},
title = {{Midkine in Host Defense.}},
url = {{http://dx.doi.org/10.1111/bph.12402}},
doi = {{10.1111/bph.12402}},
volume = {{171}},
year = {{2014}},
}