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Rates of bronchopulmonary dysplasia in very low birth weight neonates : a systematic review and meta-analysis

Moreira, Alvaro ; Noronha, Michelle ; Joy, Jooby ; Bierwirth, Noah ; Tarriela, Aina ; Naqvi, Aliha ; Zoretic, Sarah ; Jones, Maxwell ; Marotta, Ali and Valadie, Taylor , et al. (2024) In Respiratory Research 25(1).
Abstract

Importance: Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking. Objective: To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (< 32 weeks) neonates. Data sources: A search of MEDLINE from January 1990 until September 2019 using search terms related to BPD and prevalence was performed. Study selection: Randomized controlled trials and observational studies evaluating rates of BPD in very low birth weight or very low gestational age infants were eligible. Included studies defined BPD as positive pressure ventilation... (More)

Importance: Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking. Objective: To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (< 32 weeks) neonates. Data sources: A search of MEDLINE from January 1990 until September 2019 using search terms related to BPD and prevalence was performed. Study selection: Randomized controlled trials and observational studies evaluating rates of BPD in very low birth weight or very low gestational age infants were eligible. Included studies defined BPD as positive pressure ventilation or oxygen requirement at 28 days (BPD28) or at 36 weeks postmenstrual age (BPD36). Data extraction and synthesis: Two reviewers independently conducted all stages of the review. Random-effects meta-analysis was used to calculate the pooled prevalence. Subgroup analyses included gestational age group, birth weight group, setting, study period, continent, and gross domestic product. Sensitivity analyses were performed to reduce study heterogeneity. Main outcomes and measures: Prevalence of BPD defined as BPD28, BPD36, and by subgroups. Results: A total of 105 articles or databases and 780,936 patients were included in this review. The pooled prevalence was 35% (95% CI, 28-42%) for BPD28 (n = 26 datasets, 132,247 neonates), and 21% (95% CI, 19-24%) for BPD36 (n = 70 studies, 672,769 neonates). In subgroup meta-analyses, birth weight category, gestational age category, and continent were strong drivers of the pooled prevalence of BPD. Conclusions and relevance: This study provides a global estimation of BPD prevalence in very low birth weight/low gestation neonates.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bronchopulmonary dysplasia, Chronic lung disease, Meta-analysis, Prevalence, Rates
in
Respiratory Research
volume
25
issue
1
article number
219
publisher
BioMed Central (BMC)
external identifiers
  • pmid:38790002
  • scopus:85194219156
ISSN
1465-9921
DOI
10.1186/s12931-024-02850-x
language
English
LU publication?
yes
id
407b1e67-0aa0-457f-87b5-204f94ae3a89
date added to LUP
2024-12-20 13:31:41
date last changed
2025-07-05 18:55:50
@article{407b1e67-0aa0-457f-87b5-204f94ae3a89,
  abstract     = {{<p>Importance: Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking. Objective: To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (&lt; 32 weeks) neonates. Data sources: A search of MEDLINE from January 1990 until September 2019 using search terms related to BPD and prevalence was performed. Study selection: Randomized controlled trials and observational studies evaluating rates of BPD in very low birth weight or very low gestational age infants were eligible. Included studies defined BPD as positive pressure ventilation or oxygen requirement at 28 days (BPD28) or at 36 weeks postmenstrual age (BPD36). Data extraction and synthesis: Two reviewers independently conducted all stages of the review. Random-effects meta-analysis was used to calculate the pooled prevalence. Subgroup analyses included gestational age group, birth weight group, setting, study period, continent, and gross domestic product. Sensitivity analyses were performed to reduce study heterogeneity. Main outcomes and measures: Prevalence of BPD defined as BPD28, BPD36, and by subgroups. Results: A total of 105 articles or databases and 780,936 patients were included in this review. The pooled prevalence was 35% (95% CI, 28-42%) for BPD28 (n = 26 datasets, 132,247 neonates), and 21% (95% CI, 19-24%) for BPD36 (n = 70 studies, 672,769 neonates). In subgroup meta-analyses, birth weight category, gestational age category, and continent were strong drivers of the pooled prevalence of BPD. Conclusions and relevance: This study provides a global estimation of BPD prevalence in very low birth weight/low gestation neonates.</p>}},
  author       = {{Moreira, Alvaro and Noronha, Michelle and Joy, Jooby and Bierwirth, Noah and Tarriela, Aina and Naqvi, Aliha and Zoretic, Sarah and Jones, Maxwell and Marotta, Ali and Valadie, Taylor and Brick, Jonathan and Winter, Caitlyn and Porter, Melissa and Decker, Isabelle and Bruschettini, Matteo and Ahuja, Sunil K.}},
  issn         = {{1465-9921}},
  keywords     = {{Bronchopulmonary dysplasia; Chronic lung disease; Meta-analysis; Prevalence; Rates}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Respiratory Research}},
  title        = {{Rates of bronchopulmonary dysplasia in very low birth weight neonates : a systematic review and meta-analysis}},
  url          = {{http://dx.doi.org/10.1186/s12931-024-02850-x}},
  doi          = {{10.1186/s12931-024-02850-x}},
  volume       = {{25}},
  year         = {{2024}},
}