Contractile Injection Systems and Use Thereof
Rebrova, Eva Maria LU
and Taylor, Nicholas
(2023)
- Abstract (Swedish)
- The invention relates to re-engineering of a natural microbial syringe for loading of effector proteins that are not naturally found as cargo of the specific syringe. The cargo, that is one or more effector protein and proteins required for packing, can be up to 300 kDa and can be proteins such as toxins, therapeutic proteins, and gene modification tools. The re-engineering of the natural syringe result in a contractile injection system that allows packing of large cargo and cargo combinations, such as toxin-chimeras. The system comprises a Conserved Virulence Cassette encoding the syringe structure and is co-expressed with a sequence encoding cargo and a signal peptide. The signal peptide comprises a packing motif that enables packing of... (More)
- The invention relates to re-engineering of a natural microbial syringe for loading of effector proteins that are not naturally found as cargo of the specific syringe. The cargo, that is one or more effector protein and proteins required for packing, can be up to 300 kDa and can be proteins such as toxins, therapeutic proteins, and gene modification tools. The re-engineering of the natural syringe result in a contractile injection system that allows packing of large cargo and cargo combinations, such as toxin-chimeras. The system comprises a Conserved Virulence Cassette encoding the syringe structure and is co-expressed with a sequence encoding cargo and a signal peptide. The signal peptide comprises a packing motif that enables packing of cargo into the syringe. The contractile injection system can be used for agricultural purposes as well as for medicinal purposes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/407f311b-7136-47d6-b60b-d235da19d9dc
- inventor
- Rebrova, Eva Maria
LU
and Taylor, Nicholas
- publishing date
- 2023
- type
- Patent
- publication status
- submitted
- subject
- language
- Swedish
- LU publication?
- no
- id
- 407f311b-7136-47d6-b60b-d235da19d9dc
- alternative location
- https://worldwide.espacenet.com/patent/search/family/082799924/publication/WO2024003387A1?q=PCT%2FEP2023%2F068102
- date added to LUP
- 2024-06-19 13:17:15
- date last changed
- 2024-06-20 09:04:47
@misc{407f311b-7136-47d6-b60b-d235da19d9dc,
abstract = {{The invention relates to re-engineering of a natural microbial syringe for loading of effector proteins that are not naturally found as cargo of the specific syringe. The cargo, that is one or more effector protein and proteins required for packing, can be up to 300 kDa and can be proteins such as toxins, therapeutic proteins, and gene modification tools. The re-engineering of the natural syringe result in a contractile injection system that allows packing of large cargo and cargo combinations, such as toxin-chimeras. The system comprises a Conserved Virulence Cassette encoding the syringe structure and is co-expressed with a sequence encoding cargo and a signal peptide. The signal peptide comprises a packing motif that enables packing of cargo into the syringe. The contractile injection system can be used for agricultural purposes as well as for medicinal purposes.}},
author = {{Rebrova, Eva Maria and Taylor, Nicholas}},
language = {{swe}},
note = {{Patent, Patent Number: ?}},
title = {{Contractile Injection Systems and Use Thereof}},
url = {{https://worldwide.espacenet.com/patent/search/family/082799924/publication/WO2024003387A1?q=PCT%2FEP2023%2F068102}},
year = {{2023}},
}