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Greater reduction of knee than hip pain in osteoarthritis treated with naproxen, as evaluated by WOMAC and SF-36

Svensson, O ; Malmenas, M ; Fajutrao, L ; Roos, Ewa LU and Lohmander, Stefan LU (2006) In Annals of the Rheumatic Diseases 65(6). p.781-784
Abstract
Objectives: To compare the improvement of hip and knee osteoarthritis during treatment with naproxen. Methods: Men and women aged 40 to 75 years with symptomatic osteoarthritis of the knee or hip of at least three months' duration participated in a six week placebo controlled, double blind study with naproxen 500 mg twice daily as one treatment arm. Naproxen was given to 403 patients (280 knee, 123 hip) and placebo to 108 patients (75 knee, 33 hip). WOMAC (Western Ontario and McMaster Universities osteoarthritis index) 3.1 visual analogue scale and SF-36 (36 item short form health survey) were used to assess response to treatment between baseline and week 6. Results: There were no differences at baseline between knee and hip osteoarthritis... (More)
Objectives: To compare the improvement of hip and knee osteoarthritis during treatment with naproxen. Methods: Men and women aged 40 to 75 years with symptomatic osteoarthritis of the knee or hip of at least three months' duration participated in a six week placebo controlled, double blind study with naproxen 500 mg twice daily as one treatment arm. Naproxen was given to 403 patients (280 knee, 123 hip) and placebo to 108 patients (75 knee, 33 hip). WOMAC (Western Ontario and McMaster Universities osteoarthritis index) 3.1 visual analogue scale and SF-36 (36 item short form health survey) were used to assess response to treatment between baseline and week 6. Results: There were no differences at baseline between knee and hip osteoarthritis for any of the WOMAC subscales or SF-36 domains. Improvement was between 4 and 7 mm greater for knee than for hip for all WOMAC subscales (pain, Delta = 4.7 mm (p = 0.03); stiffness, Delta = 6.6 mm (p = 0.004); function, Delta = 4.8 mm (p = 0.06)). Effect size was about 0.8 for all WOMAC subscales for the knee and between 0.5 and 0.6 for the hip. Knee patients treated with naproxen improved 4.6 (p = 0.033) more than hip patients for SF- 36 bodily pain and 10.3 (p = 0.014) more for SF- 36 role-physical. Conclusions: Patients with knee osteoarthritis improved more with naproxen treatment than patients with hip osteoarthritis, as monitored by WOMAC and the SF-36 domains bodily pain and role-physical. These findings warrant further investigation and strongly suggest that efficacy of treatment of osteoarthritis of knee and hip should be evaluated separately. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
65
issue
6
pages
781 - 784
publisher
BMJ Publishing Group
external identifiers
  • wos:000237513300015
  • pmid:16269428
  • scopus:33744474828
  • pmid:16269428
ISSN
1468-2060
DOI
10.1136/ard.2005.040519
language
English
LU publication?
yes
id
0835ddc2-6cec-4726-abe8-22f309df2e9a (old id 409838)
date added to LUP
2016-04-01 16:02:13
date last changed
2021-09-08 01:20:54
@article{0835ddc2-6cec-4726-abe8-22f309df2e9a,
  abstract     = {Objectives: To compare the improvement of hip and knee osteoarthritis during treatment with naproxen. Methods: Men and women aged 40 to 75 years with symptomatic osteoarthritis of the knee or hip of at least three months' duration participated in a six week placebo controlled, double blind study with naproxen 500 mg twice daily as one treatment arm. Naproxen was given to 403 patients (280 knee, 123 hip) and placebo to 108 patients (75 knee, 33 hip). WOMAC (Western Ontario and McMaster Universities osteoarthritis index) 3.1 visual analogue scale and SF-36 (36 item short form health survey) were used to assess response to treatment between baseline and week 6. Results: There were no differences at baseline between knee and hip osteoarthritis for any of the WOMAC subscales or SF-36 domains. Improvement was between 4 and 7 mm greater for knee than for hip for all WOMAC subscales (pain, Delta = 4.7 mm (p = 0.03); stiffness, Delta = 6.6 mm (p = 0.004); function, Delta = 4.8 mm (p = 0.06)). Effect size was about 0.8 for all WOMAC subscales for the knee and between 0.5 and 0.6 for the hip. Knee patients treated with naproxen improved 4.6 (p = 0.033) more than hip patients for SF- 36 bodily pain and 10.3 (p = 0.014) more for SF- 36 role-physical. Conclusions: Patients with knee osteoarthritis improved more with naproxen treatment than patients with hip osteoarthritis, as monitored by WOMAC and the SF-36 domains bodily pain and role-physical. These findings warrant further investigation and strongly suggest that efficacy of treatment of osteoarthritis of knee and hip should be evaluated separately.},
  author       = {Svensson, O and Malmenas, M and Fajutrao, L and Roos, Ewa and Lohmander, Stefan},
  issn         = {1468-2060},
  language     = {eng},
  number       = {6},
  pages        = {781--784},
  publisher    = {BMJ Publishing Group},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Greater reduction of knee than hip pain in osteoarthritis treated with naproxen, as evaluated by WOMAC and SF-36},
  url          = {http://dx.doi.org/10.1136/ard.2005.040519},
  doi          = {10.1136/ard.2005.040519},
  volume       = {65},
  year         = {2006},
}