Are cortical microvascular raspberries caused by cerebral hypoperfusion? An exploratory pathological study
Ek Olofsson, Henric LU
; Haglund, Mattias
LU
and Englund, Elisabet
LU
(2021)
In Cerebral Circulation - Cognition and Behavior
2.
- Abstract
Introduction: This retrospective study investigated a cortical microvascular formation, termed a ‘raspberry’ due to its appearance under a bright-field microscope. We examined whether there is support for the hypothesis that raspberry formation is an angiogenic process induced by cerebral hypoperfusion. Materials and Methods: Raspberries were manually quantified in haematoxylin and eosin-stained cortical sections from the anterior frontal lobe of deceased individuals who had undergone a diagnostic neuropathological examination at the Department of Pathology, Lund, Sweden, during April 2019–January 2021. Subjects represented consecutively received cases during this 22-month period. The raspberry density was compared between subjects... (More)
Introduction: This retrospective study investigated a cortical microvascular formation, termed a ‘raspberry’ due to its appearance under a bright-field microscope. We examined whether there is support for the hypothesis that raspberry formation is an angiogenic process induced by cerebral hypoperfusion. Materials and Methods: Raspberries were manually quantified in haematoxylin and eosin-stained cortical sections from the anterior frontal lobe of deceased individuals who had undergone a diagnostic neuropathological examination at the Department of Pathology, Lund, Sweden, during April 2019–January 2021. Subjects represented consecutively received cases during this 22-month period. The raspberry density was compared between subjects according to variables collected from medical records and autopsy reports: age, sex, hypertension, diabetes mellitus, atrial fibrillation, orthostatic hypotension, chronic heart failure, acute circulatory failure, aortic atherosclerosis, atherosclerosis of the basal cerebral arteries (referred to as ‘cerebral atherosclerosis’), cerebral small vessel disease, cerebral amyloid angiopathy, cerebral infarction, and ischaemic white matter disease. Results: 62 subjects were included. The mean age was 71.9 years (range 46–97 years). 21 subjects (33.9%) were female. Independent-samples t-test showed a higher raspberry density in subjects with cerebral atherosclerosis (p = 0.029; 95% CI 0.7, 11.6 raspberries/cm²). The higher raspberry density in subjects with cerebral atherosclerosis remained in multiple linear regression (p = 0.003; 95% CI 2.3, 11.1 raspberries/cm²). Conclusion: This exploratory study indicates that cortical raspberries could be associated with cerebral atherosclerosis. The remaining results were inconclusive but motivate further examination of variables such as acute circulatory failure.
(Less)
- author
- Ek Olofsson, Henric
LU
; Haglund, Mattias
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cerebral angiogenesis, Cerebral hypoperfusion, Cerebral ischemia, Cerebral neovascularization, Cerebrovascular disease
- in
- Cerebral Circulation - Cognition and Behavior
- volume
- 2
- article number
- 100026
- publisher
- Elsevier
- external identifiers
-
- scopus:85127014886
- ISSN
- 2666-2450
- DOI
- 10.1016/j.cccb.2021.100026
- project
- A new type of microvascular formation in the cerebral cortex – is there a link to cerebral hypoperfusion?
- language
- English
- LU publication?
- yes
- id
- 40d2221e-602d-4194-8d2f-3a59610940d3
- date added to LUP
- 2022-05-03 13:20:16
- date last changed
- 2023-12-19 21:37:45
@article{40d2221e-602d-4194-8d2f-3a59610940d3,
abstract = {{<p>Introduction: This retrospective study investigated a cortical microvascular formation, termed a ‘raspberry’ due to its appearance under a bright-field microscope. We examined whether there is support for the hypothesis that raspberry formation is an angiogenic process induced by cerebral hypoperfusion. Materials and Methods: Raspberries were manually quantified in haematoxylin and eosin-stained cortical sections from the anterior frontal lobe of deceased individuals who had undergone a diagnostic neuropathological examination at the Department of Pathology, Lund, Sweden, during April 2019–January 2021. Subjects represented consecutively received cases during this 22-month period. The raspberry density was compared between subjects according to variables collected from medical records and autopsy reports: age, sex, hypertension, diabetes mellitus, atrial fibrillation, orthostatic hypotension, chronic heart failure, acute circulatory failure, aortic atherosclerosis, atherosclerosis of the basal cerebral arteries (referred to as ‘cerebral atherosclerosis’), cerebral small vessel disease, cerebral amyloid angiopathy, cerebral infarction, and ischaemic white matter disease. Results: 62 subjects were included. The mean age was 71.9 years (range 46–97 years). 21 subjects (33.9%) were female. Independent-samples t-test showed a higher raspberry density in subjects with cerebral atherosclerosis (p = 0.029; 95% CI 0.7, 11.6 raspberries/cm²). The higher raspberry density in subjects with cerebral atherosclerosis remained in multiple linear regression (p = 0.003; 95% CI 2.3, 11.1 raspberries/cm²). Conclusion: This exploratory study indicates that cortical raspberries could be associated with cerebral atherosclerosis. The remaining results were inconclusive but motivate further examination of variables such as acute circulatory failure.</p>}},
author = {{Ek Olofsson, Henric and Haglund, Mattias and Englund, Elisabet}},
issn = {{2666-2450}},
keywords = {{Cerebral angiogenesis; Cerebral hypoperfusion; Cerebral ischemia; Cerebral neovascularization; Cerebrovascular disease}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Cerebral Circulation - Cognition and Behavior}},
title = {{Are cortical microvascular raspberries caused by cerebral hypoperfusion? An exploratory pathological study}},
url = {{http://dx.doi.org/10.1016/j.cccb.2021.100026}},
doi = {{10.1016/j.cccb.2021.100026}},
volume = {{2}},
year = {{2021}},
}