Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study
(2006) In Swedish Dental Journal 30(1). p.17-23- Abstract
- The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment but yet showing signs of recurrent disease. Genotyping of the IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] polymorphisms was carried out using an allelic discrimination Assay-by-Design method on ABI PRISM 7900 Sequence Detection System. All genotypes were analyzed using the GeneMapper 2.0 software. A similar distribution... (More)
- The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment but yet showing signs of recurrent disease. Genotyping of the IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] polymorphisms was carried out using an allelic discrimination Assay-by-Design method on ABI PRISM 7900 Sequence Detection System. All genotypes were analyzed using the GeneMapper 2.0 software. A similar distribution of Single Nucleotide Polymorphism (SNP) was seen in both groups. Analysis by logistic regression including gender, IL-1 alpha [+4845C>T], IL-1 beta [-3954C>T], IL-6 [-174G>C] genotypes, the composite IL-1 genotype, the combination of the composite IL-1 genotype and the IL-6 -174G>C genotype and adjusting for smoking did not result in any statistically significant difference. SNPs in IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] do not seem to increase the susceptibility to chronic periodontitis in this group of subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/410232
- author
- Jansson, H ; Lyssenko, Valeriya LU ; Gustavsson, A ; Hamberg, K ; Soderfeldt, B ; Groop, Leif LU and Bratthall, G
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- interleukin-7, genotype, periodontal diseases, interleukin-6, polymorphism
- in
- Swedish Dental Journal
- volume
- 30
- issue
- 1
- pages
- 17 - 23
- publisher
- Sveriges Tandläkarförbund
- external identifiers
-
- pmid:16708852
- wos:000237318800003
- scopus:33646374428
- ISSN
- 0347-9994
- language
- English
- LU publication?
- yes
- id
- d64e2454-f7b7-497f-9aec-34c1e8c47712 (old id 410232)
- date added to LUP
- 2016-04-01 16:16:32
- date last changed
- 2024-01-11 05:02:28
@article{d64e2454-f7b7-497f-9aec-34c1e8c47712, abstract = {{The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment but yet showing signs of recurrent disease. Genotyping of the IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] polymorphisms was carried out using an allelic discrimination Assay-by-Design method on ABI PRISM 7900 Sequence Detection System. All genotypes were analyzed using the GeneMapper 2.0 software. A similar distribution of Single Nucleotide Polymorphism (SNP) was seen in both groups. Analysis by logistic regression including gender, IL-1 alpha [+4845C>T], IL-1 beta [-3954C>T], IL-6 [-174G>C] genotypes, the composite IL-1 genotype, the combination of the composite IL-1 genotype and the IL-6 -174G>C genotype and adjusting for smoking did not result in any statistically significant difference. SNPs in IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] do not seem to increase the susceptibility to chronic periodontitis in this group of subjects.}}, author = {{Jansson, H and Lyssenko, Valeriya and Gustavsson, A and Hamberg, K and Soderfeldt, B and Groop, Leif and Bratthall, G}}, issn = {{0347-9994}}, keywords = {{interleukin-7; genotype; periodontal diseases; interleukin-6; polymorphism}}, language = {{eng}}, number = {{1}}, pages = {{17--23}}, publisher = {{Sveriges Tandläkarförbund}}, series = {{Swedish Dental Journal}}, title = {{Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study}}, volume = {{30}}, year = {{2006}}, }